MTF2

MTF2 (Metal Response Element Binding Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF19.

Full Name

METAL RESPONSE ELEMENT BINDING TRANSCRIPTION FACTOR 2

Function

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557).

Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity).

Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity).

Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity).

In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity).

Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

Biological Process

Cellular response to leukemia inhibitory factor Source: Ensembl
Chromatin organization Source: GO_Central
Negative regulation of histone H3-K27 methylation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of histone H3-K27 methylation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Segment specification Source: UniProtKB
Stem cell differentiation Source: UniProtKB
Stem cell population maintenance Source: UniProtKB

Cellular Location

Nucleus
Note: Localizes to chromatin as part of the PRC2 complex.