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  • Rabbit Anti-MTHFD1L Recombinant Antibody (D7O8E )

Rabbit Anti-MTHFD1L Recombinant Antibody (D7O8E ) (CBMAB-CP1598-LY)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
D7O8E
Application
WB, IP
Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro52 of human MTHFD1L protein.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like
Introduction
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Entrez Gene ID
25902
UniProt ID
Q6UB35
Alternative Names
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like; Monofunctional C1-Tetrahydrofolate Synthase; Mitochondrial; Formyltetrahydrofolate Synthetase Domain Containing 1; 10-Formyl-THF Synthetase; EC 6.3.4.3; FTHFSDC1;
Function
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2.
Biological Process
10-formyltetrahydrofolate biosynthetic process Source: BHF-UCL
Embryonic neurocranium morphogenesis Source: BHF-UCL
Embryonic viscerocranium morphogenesis Source: BHF-UCL
Folic acid-containing compound metabolic process Source: BHF-UCL
Formate metabolic process Source: BHF-UCL
Neural tube closure Source: BHF-UCL
Tetrahydrofolate interconversion Source: GO_Central
Cellular Location
Mitochondrion

Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., ... & Meiser, J. (2023). Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism, 5(4), 642-659.

Rao, K., Zheng, K., Zhao, Q., He, J., Zhou, B., Hou, G., ... & Xia, Q. (2023). The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth. Cellular Oncology, 46(3), 735-744.

Meng, Q., Lu, Y. X., Wei, C., Wang, Z. X., Lin, J. F., Liao, K., ... & Ju, H. Q. (2022). Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis. Oncogene, 41(32), 3912-3924.

Vohra, M., Adhikari, P., CD, S., Nagri, S. K., Umakanth, S., Satyamoorthy, K., & Rai, P. S. (2020). CpG-SNP site methylation regulates allele-specific expression of MTHFD1 gene in type 2 diabetes. Laboratory Investigation, 100(8), 1090-1101.

Bidla, G., Watkins, D., Chéry, C., Froese, D. S., Ells, C., Kerachian, M., ... & Rosenblatt, D. S. (2020). Biochemical analysis of patients with mutations in MTHFD1 and a diagnosis of methylenetetrahydrofolate dehydrogenase 1 deficiency. Molecular Genetics and Metabolism, 130(3), 179-182.

Xu, M., Li, J., Chen, X., Han, L., Li, L., & Liu, Y. (2019). MTHFD1 promoter hypermethylation increases the risk of hypertension. Clinical and Experimental Hypertension, 41(5), 422-427.

Sdelci, S., Rendeiro, A. F., Rathert, P., You, W., Lin, J. M. G., Ringler, A., ... & Kubicek, S. (2019). MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nature genetics, 51(6), 990-998.

Yu, H., Wang, H., Xu, H. R., Zhang, Y. C., Yu, X. B., Wu, M. C., ... & Cong, W. M. (2019). Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence. Future Oncology, 15(15), 1771-1780.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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