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Mouse Anti-MTMR3 Recombinant Antibody (1E11) (CBMAB-A5669-LY)

The product is antibody recognizes MTMR3. The antibody 1E11 immunoassay techniques such as: WB, ELISA.
See all MTMR3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MTMR3 (NP_066576.1, 579 a.a. ~ 674 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
myotubularin related protein 3
Introduction
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
8897
UniProt ID
Q13615
Alternative Names
FLJ32333; FYVE-DSP1; KIAA0371; ZFYVE10
Function
Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921).

Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921).

May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Biological Process
Cellular response to glucose starvation Source: ParkinsonsUK-UCL
Macroautophagy Source: Reactome
Phosphatidylinositol 5-phosphate metabolic process Source: ParkinsonsUK-UCL
Phosphatidylinositol biosynthetic process Source: Reactome
Phosphatidylinositol dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: UniProtKB
Regulation of autophagosome assembly Source: ParkinsonsUK-UCL
Regulation of autophagy Source: GO_Central
Regulation of phosphatidylinositol dephosphorylation Source: UniProtKB
Cellular Location
Cytoplasm
Other locations
Membrane

Elhelaly, M., Shaker, O. G., Ayeldeen, G., Elsergany, A. R., & Mostafa, N. (2023). Breast cancer risk is associated with the HULC rs7763881, MTMR3 rs12537 polymorphisms, and serum levels of HULC and MTMR3 in Egyptian patients. Molecular Biology Reports, 50(12), 10073-10081.

Wang, Y. N., Gan, T., Qu, S., Xu, L. L., Hu, Y., Liu, L. J., ... & Zhang, H. (2023). MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy. Kidney International, 104(3), 562-576.

Ayoub, S. E., Shaker, O. G., Aboshama, R. A., Etman, M. K., Khalefa, A. A., Zaki, O. M., ... & Ali, M. A. (2023). Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia. Non-coding RNA Research, 8(4), 481-486.

Liu, Z., Yang, Y., Ju, J., Zhang, G., Zhang, P., Ji, P., ... & Hou, R. (2022). miR-100-5p promotes epidermal stem cell proliferation through targeting MTMR3 to activate PIP3/AKT and ERK signaling pathways. Stem Cells International, 2022.

Cao, X., Tang, S., Du, F., Li, H., Shen, X., Li, D., ... & Yin, H. (2020). miR-99a-5p regulates the proliferation and differentiation of skeletal muscle satellite cells by targeting MTMR3 in chicken. Genes, 11(4), 369.

Sun, G., Li, Z., He, Z., Wang, W., Wang, S., Zhang, X., ... & Xu, Z. (2020). Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. Journal of Experimental & Clinical Cancer Research, 39, 1-17.

Wang, B., Mao, J. H., Wang, B. Y., Wang, L. X., Wen, H. Y., Xu, L. J., ... & Yang, H. (2020). Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway. Cancer letters, 489, 87-99.

Putri, D. D. P., Kawasaki, T., Murase, M., Sueyoshi, T., Deguchi, T., Ori, D., ... & Kawai, T. (2019). PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking. Journal of Biological Chemistry, 294(21), 8412-8423.

Senousy, M. A., Helmy, H. S., Fathy, N., Shaker, O. G., & Ayeldeen, G. M. (2019). Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients. Scientific Reports, 9(1), 12299.

Wang, Z., Zhang, M., Shan, R., Wang, Y. J., Chen, J., Huang, J., ... & Zhou, W. B. (2019). MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells. Oncology Reports, 42(5), 1915-1923.

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For research use only. Not intended for any clinical use.

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