MTMR3

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

myotubularin related protein 3

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921).

Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921).

May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).

Biological Process

Cellular response to glucose starvation Source: ParkinsonsUK-UCL
Macroautophagy Source: Reactome
Phosphatidylinositol 5-phosphate metabolic process Source: ParkinsonsUK-UCL
Phosphatidylinositol biosynthetic process Source: Reactome
Phosphatidylinositol dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: UniProtKB
Regulation of autophagosome assembly Source: ParkinsonsUK-UCL
Regulation of autophagy Source: GO_Central
Regulation of phosphatidylinositol dephosphorylation Source: UniProtKB

Cellular Location

Cytoplasm
Other locations
Membrane