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Mouse Anti-MTSS1 Recombinant Antibody (A1202) (CBMAB-AP4874LY)

The product is antibody recognizes MTSS1. The antibody A1202 immunoassay techniques such as: ELISA, IF, IHC, WB.
See all MTSS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A1202
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Peptide Sequence - KPSIPEEHRQ (amino acids 679 - 688)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MTSS1, I-BAR Domain Containing
Introduction
MTSS1 (MTSS1, I-BAR Domain Containing) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Hedgehog Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is MTSS1L.
Entrez Gene ID
9788
UniProt ID
O43312
Alternative Names
MTSS1, I-BAR Domain Containing; Missing In Metastasis Protein; Metastasis Suppressor YGL-1; Metastasis Suppressor 1; MIM; Metastasis Suppressor Protein 1;
Function
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Adherens junction maintenance Source: GO_Central
Cell adhesion Source: UniProtKB
Cellular response to fluid shear stress Source: UniProtKB
Epithelial cell proliferation involved in renal tubule morphogenesis Source: UniProtKB
Glomerulus morphogenesis Source: UniProtKB
Microspike assembly Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Nephron tubule epithelial cell differentiation Source: UniProtKB
Plasma membrane organization Source: InterPro
Positive regulation of actin filament bundle assembly Source: GO_Central
Renal tubule morphogenesis Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Cytoskeleton

Wang, Y., Jia, Z., Liang, C., He, Y., Cong, M., Wu, Q., ... & Hu, G. (2023). MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. Cell Discovery, 9(1), 20.

Wu, M., Qiu, Q., Zhou, Q., Li, J., Yang, J., Zheng, C., ... & Lu, Y. (2022). circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer. Molecular Cancer, 21(1), 1-19.

Grandits, A. M., Nguyen, C. H., Schlerka, A., Hackl, H., Sill, H., Etzler, J., ... & Wieser, R. (2021). Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness. Leukemia, 35(10), 2827-2839.

Grandits, A. M., & Wieser, R. (2021). Gene expression changes contribute to stemness and therapy resistance of relapsed acute myeloid leukemia: roles of SOCS2, CALCRL, MTSS1, and KDM6A. Experimental hematology, 99, 1-11.

Chen, J. X., Wang, Y. P., Zhang, X., Li, G. X., Zheng, K., & Duan, C. Z. (2020). lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice. Brain research bulletin, 162, 20-29.

Cong, M., Wang, Y., Yang, Y., Lian, C., Zhuang, X., Li, X., ... & Hu, G. (2020). MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. Nature Cancer, 1(2), 222-234.

Chen, J., Huang, L., Zhu, Q., Wang, Z., & Tang, Z. (2020). MTSS1 hypermethylation is associated with prostate cancer progression. Journal of cellular physiology, 235(3), 2687-2697.

Hu, Y., Wang, F., Xu, F., Fang, K., Fang, Z., Shuai, X., ... & Zhao, G. (2020). A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer. Theranostics, 10(22), 10120.

Liu, K., Jiao, X. D., Hao, J. L., Qin, B. D., Wu, Y., Chen, W., ... & Zang, Y. S. (2019). MTSS1 inhibits metastatic potential and induces G2/M phase cell cycle arrest in gastric cancer. OncoTargets and therapy, 12, 5143.

Morley, M. P., Wang, X., Hu, R., Brandimarto, J., Tucker, N. R., Felix, J. F., ... & Cappola, T. P. (2019). Cardioprotective effects of MTSS1 enhancer variants. Circulation, 139(17), 2073-2076.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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