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Mouse Anti-MTUS1 (AA 1-241) Recombinant Antibody (CBFYM-0476) (CBMAB-M0604-FY)

This product is mouse antibody that recognizes MTUS1. The antibody CBFYM-0476 can be used for immunoassay techniques such as: ELISA, WB.
See all MTUS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0476
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-241

Target

Full Name
mitochondrial tumor suppressor 1
Introduction
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
Entrez Gene ID
57509
UniProt ID
Q9ULD2
Alternative Names
Microtubule Associated Scaffold Protein 1; Angiotensin-II Type 2 Receptor-Interacting Protein; Microtubule Associated Tumor Suppressor 1; Mitochondrial Tumor Suppressor Gene 1; AT2 Receptor-Interacting Protein; Mitochondrial Tumor Suppressor 1; AT2 Receptor-Binding Protein; AT2R Binding Protein; MTSG1; ATBP
Function
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Biological Process
Regulation of macrophage chemotaxis Source: GO_Central
Cellular Location
Nucleus
Mitochondrion
Plasma membrane
Cell membrane
Golgi apparatus
Note: In neurons, translocates into the nucleus after treatment with angiotensin-II.By similarity
Isoform 1:
Cytoskeleton
centrosome
spindle
Note: Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
Involvement in disease
Hepatocellular carcinoma (HCC):
A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Chen-Xi, G., Jin-Fu, X., An-Quan, H., Xiao, Y., Ying-Hui, W., Suo-Yuan, L., ... & Jun, S. (2023). Long non-coding RNA PRR7-AS1 promotes osteosarcoma progression via binding RNF2 to transcriptionally suppress MTUS1. Frontiers in Oncology, 13.

Cheng, L. Y., Huang, M. S., Zhong, H. G., Ru, H. M., Mo, S. S., Wei, C. Y., ... & Tang, W. Z. (2022). MTUS1 is a promising diagnostic and prognostic biomarker for colorectal cancer. World Journal of Surgical Oncology, 20(1), 1-15.

Jee, S., Kim, H., Bang, S., Kim, Y., Park, H. Y., Paik, S. S., ... & Jang, K. (2021). Low-level expression of MTUS1 is associated with poor survival in patients with lung adenocarcinoma. Diagnostics, 11(7), 1250.

Rozario, L. T., Sharker, T., & Nila, T. A. (2021). In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function. PloS one, 16(6), e0252932.

Ranjan, N., Pandey, V., Panigrahi, M. K., Klumpp, L., Naumann, U., & Babu, P. P. (2021). The tumor suppressor mtus1/atip1 modulates tumor promotion in glioma: Association with epigenetics and dna repair. Cancers, 13(6), 1245.

Lv, Q., Dong, F., Zhou, Y., Cai, Z., & Wang, G. (2020). RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability. Cell Death & Disease, 11(12), 1056.

Sim, J., Kim, Y., Kim, H., Bang, S., Jee, S., Park, S., ... & Jang, K. (2020). Loss of MTUS1 expression is associated with poor prognosis in patients with gallbladder carcinoma. in vivo, 34(1), 125-132.

Sim, J., Wi, Y. C., Park, H. Y., Park, S. Y., Yoon, Y. E., Bang, S., ... & Shin, S. J. (2020). Clinicopathological significance of MTUS1 expression in patients with renal cell carcinoma. Anticancer Research, 40(5), 2961-2967.

Ou, L., Xiang, T. Y., Hao, X. Y., Wang, D. Z., & Zeng, Q. (2020). Reduced long non-coding RNA PTENP1 contributed to proliferation and invasion via miR-19b/MTUS1 axis in patients with cervical cancer. European Review for Medical & Pharmacological Sciences, 24(8).

Lv, D. B., Zhang, J. Y., Gao, K., Yu, Z. H., Sheng, W. C., Yang, G., & Gao, Y. Z. (2019). MicroRNA-765 targets MTUS1 to promote the progression of osteosarcoma via mediating ERK/EMT pathway. European Review for Medical & Pharmacological Sciences, 23(11).

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For research use only. Not intended for any clinical use.

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