MTUS1

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq]

Full Name

mitochondrial tumor suppressor 1

Function

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

Biological Process

Regulation of macrophage chemotaxis Source: GO_Central

Cellular Location

Nucleus
Mitochondrion
Plasma membrane
Cell membrane
Golgi apparatus
Note: In neurons, translocates into the nucleus after treatment with angiotensin-II.By similarity
Isoform 1:
Cytoskeleton
centrosome
spindle
Note: Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Involvement in disease

Hepatocellular carcinoma (HCC):
A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.