Mouse Anti-MTX1 Recombinant Antibody (CBFYM-2778) (CBMAB-M2971-FY)

Name: Mouse Anti-MTX1 Recombinant Antibody (CBFYM-2778)
SKU: CBMAB-M2971-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2778

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

METAXIN 1

Introduction

MTX1 is a Protein Coding gene. Diseases associated with MTX1 include Gaucher's Disease. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. An important paralog of this gene is MTX3.

Entrez Gene ID

4580

UniProt ID

Q13505

Alternative Names

Metaxin 1; Mitochondrial Outer Membrane Import Complex Protein 1; MTXN; MTX; Metaxin-1

Function

Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).

Biological Process

Inner mitochondrial membrane organization Source: UniProtKB
Lactation Source: Ensembl
Mitochondrion organization Source: GO_Central
Protein insertion into mitochondrial outer membrane Source: ComplexPortal

Cellular Location

Mitochondrion
Mitochondrion outer membrane
Other locations
Membrane

Topology

Helical: 421-441

PTM

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

More Infomation

References

Zhao, Y., Song, E., Wang, W., Hsieh, C. H., Wang, X., Feng, W., ... & Shen, K. (2021). Metaxins are core components of mitochondrial transport adaptor complexes. Nature communications, 12(1), 83.

Li, L., Yu, S., Hu, Q., Hai, Y., & Li, Y. (2021). Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy. International Journal of Biological Sciences, 17(12), 3133.

Adolph, K. W. (2020). Invertebrate metaxins 1 and 2: widely distributed proteins homologous to vertebrate metaxins implicated in protein import into mitochondria. bioRxiv, 2020-01.

Adolph, K. W. (2020). Plant and bacterial metaxin-like proteins: novel proteins related to vertebrate metaxins involved in uptake of nascent proteins into mitochondria. bioRxiv, 2020-03.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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