Human Anti-MUC13 Recombinant Antibody (CBFYM-0398) (CBMAB-M0502-FY)

This product is human antibody that recognizes MUC13. The antibody CBFYM-0398 can be used for immunoassay techniques such as: FC.
See all MUC13 antibodies

Datasheet

Summary

Host Animal

Human

Specificity

Human

Clone

CBFYM-0398

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.05% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MUCIN 13, CELL SURFACE ASSOCIATED

Introduction

Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues.

Entrez Gene ID

56667

UniProt ID

Q9H3R2

Alternative Names

Mucin 13, Cell Surface Associated; Down-Regulated In Colon Cancer 1; Mucin 13, Epithelial Transmembrane; MUC-13; DRCC1; Mucin-13; RECC

Function

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

Biological Process

Maintenance of gastrointestinal epithelium Source: UniProtKB

Cellular Location

Secreted
Plasma membrane
Cell membrane
Apical cell membrane
Note: Also exists as a soluble form.

Topology

Extracellular: 19-421
Helical: 422-442
Cytoplasmic: 443-512

PTM

Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.
Highly N-glycosylated.

References

McGuckin, M. A., Davies, J. M., Felgner, P., Wong, K. Y., Giri, R., He, Y., ... & Sheng, Y. H. (2023). MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier. Cellular and Molecular Gastroenterology and Hepatology, 16(6), 985-1009.

Han, Y., Chen, G., Liu, S., Zhou, G., Xu, X., Zhang, H., ... & Chen, G. (2023). MUC13 promotes the development of esophageal cancer by upregulating the expression of o-glycan process-related molecules. Discover Oncology, 14(1), 123.

Ren, A. H., Filippou, P. S., Soosaipillai, A., Dimitrakopoulos, L., Korbakis, D., Leung, F., ... & Diamandis, E. P. (2023). Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: potential to complement CA125 in detecting non-serous subtypes. Clinical Chemistry and Laboratory Medicine (CCLM), 61(3), 464-472.

Tiemin, P., Fanzheng, M., Peng, X., Jihua, H., Ruipeng, S., Yaliang, L., ... & Lianxin, L. (2020). MUC13 promotes intrahepatic cholangiocarcinoma progression via EGFR/PI3K/AKT pathways. Journal of hepatology, 72(4), 761-773.

Massey, A. E., Doxtater, K. A., Yallapu, M. M., & Chauhan, S. C. (2020). Biophysical changes caused by altered MUC13 expression in pancreatic cancer cells. Micron, 130, 102822.

Sheng, Y. H., Wong, K. Y., Seim, I., Wang, R., He, Y., Wu, A., ... & McGuckin, M. A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38(48), 7294-7310.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-MUC13 Recombinant Antibody (CBFYM-2792)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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