Sign in or Register   Sign in or Register
  |  

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0424) (CBMAB-M0538-FY)

This product is mouse antibody that recognizes MUC2. The antibody CBFYM-0424 can be used for immunoassay techniques such as: IHC-Fr, FC, IF, IP, IHC-P, WB.
See all MUC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0424
Antibody Isotype
IgG1
Application
IHC-Fr, FC, IF, IP, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mucin 2, Oligomeric Mucus/Gel-Forming
Introduction
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Entrez Gene ID
4583
UniProt ID
Q02817
Alternative Names
Mucin 2, Oligomeric Mucus/Gel-Forming; Mucin 2, Intestinal/Tracheal; MUC-2; SMUC; Intestinal Mucin-2; Mucin-2; MLP
Function
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Biological Process
Maintenance of gastrointestinal epithelium Source: UniProtKB
Cellular Location
Secreted
Note: In the intestine, secreted into the inner and outer mucus layers.
PTM
O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Leon-Coria, A., Kumar, M., Workentine, M., Moreau, F., Surette, M., & Chadee, K. (2021). Muc2 mucin and nonmucin microbiota confer distinct innate host defense in disease susceptibility and colonic injury. Cellular and Molecular Gastroenterology and Hepatology, 11(1), 77-98.

Yao, D., Dai, W., Dong, M., Dai, C., & Wu, S. (2021). MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis. EBioMedicine, 74.

Liu, Y., Yu, X., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020). The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression. International Journal of Biological Macromolecules, 164, 884-891.

Borisova, M. A., Achasova, K. M., Morozova, K. N., Andreyeva, E. N., Litvinova, E. A., Ogienko, A. A., ... & Kozhevnikova, E. N. (2020). Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium. Scientific reports, 10(1), 21135.

Cornick, S., Kumar, M., Moreau, F., Gaisano, H., & Chadee, K. (2019). VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis. Nature communications, 10(1), 4306.

Astashchanka, A., Shroka, T. M., & Jacobsen, B. M. (2019). Mucin 2 (MUC2) modulates the aggressiveness of breast cancer. Breast cancer research and treatment, 173, 289-299.

Bademler, S., Zirtiloglu, A., Sari, M., Ucuncu, M. Z., Dogru, E. B., & Karabulut, S. (2019). Clinical significance of serum membrane-bound mucin-2 levels in breast cancer. Biomolecules, 9(2), 40.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0424)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare