MUC2
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]
Full Name
Mucin 2, Oligomeric Mucus/Gel-Forming
Function
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Biological Process
Maintenance of gastrointestinal epithelium Source: UniProtKB
Cellular Location
Secreted
Note: In the intestine, secreted into the inner and outer mucus layers.
Note: In the intestine, secreted into the inner and outer mucus layers.
PTM
O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
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Anti-MUC2 antibodies
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CompareTarget: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1238
Application*: FC, IF, IHC
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1237
Application*: FC, IF, IHC
Target: MUC2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1236
Application*: IHC
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1235
Application*: FC, IF, IHC
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1234
Application*: FC, IF, IHC
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1233
Application*: ICC, IHC, IP, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1232
Application*: ELISA, IHC
Target: MUC2
Host: Mouse
Specificity: Human
Clone: IHC624
Application*: IH
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A8
Application*: IF, E
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4A4
Application*: E, E
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H2
Application*: E, E
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D10
Application*: E, E
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 996/1
Application*: F, IH, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 994/152
Application*: E, IH
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2804
Application*: F
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2803
Application*: E, IF
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2802
Application*: E
Target: MUC2
Host: Mouse
Specificity: Human
Clone: CBFYM-2801
Application*: WB, IC, P, C, E
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2800
Application*: E, F, C, P, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0746
Application*: IH, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0745
Application*: IH, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0424
Application*: C, F, IF, IP, P, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0365
Application*: F, IF, P
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0254
Application*: E, F, IF, IH, IP, WB
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYM-0229
Application*: WB, F, P, C
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0228
Application*: E
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3708
Application*: IH, F
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2039
Application*: IH, F
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3885
Application*: F
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3187
Application*: F
Target: MUC2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MRQ-18
Application*: ELISA
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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