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Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408)


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Tested Data
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in ELISA
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in ELISA
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in WB
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in WB
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in WB
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in WB
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in FC
Mouse Anti-MUC2 Recombinant Antibody (CBT3187) (V2LY-0625-LY1408) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3187
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human MUC2 (AA: 4373-4557) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
4583
UniProt ID
Q02817
Function
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Biological Process
Maintenance of gastrointestinal epithelium Source: UniProtKB
Cellular Location
Secreted
Note: In the intestine, secreted into the inner and outer mucus layers.
PTM
O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
More Infomation

Leon-Coria, A., Kumar, M., Workentine, M., Moreau, F., Surette, M., & Chadee, K. (2021). Muc2 mucin and nonmucin microbiota confer distinct innate host defense in disease susceptibility and colonic injury. Cellular and Molecular Gastroenterology and Hepatology, 11(1), 77-98.

Yao, D., Dai, W., Dong, M., Dai, C., & Wu, S. (2021). MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis. EBioMedicine, 74.

Liu, Y., Yu, X., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020). The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression. International Journal of Biological Macromolecules, 164, 884-891.

Borisova, M. A., Achasova, K. M., Morozova, K. N., Andreyeva, E. N., Litvinova, E. A., Ogienko, A. A., ... & Kozhevnikova, E. N. (2020). Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium. Scientific reports, 10(1), 21135.

Cornick, S., Kumar, M., Moreau, F., Gaisano, H., & Chadee, K. (2019). VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis. Nature communications, 10(1), 4306.

Astashchanka, A., Shroka, T. M., & Jacobsen, B. M. (2019). Mucin 2 (MUC2) modulates the aggressiveness of breast cancer. Breast cancer research and treatment, 173, 289-299.

Bademler, S., Zirtiloglu, A., Sari, M., Ucuncu, M. Z., Dogru, E. B., & Karabulut, S. (2019). Clinical significance of serum membrane-bound mucin-2 levels in breast cancer. Biomolecules, 9(2), 40.

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For research use only. Not intended for any clinical use.

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