Mouse Anti-MUC2 (AA 5081-5179) Recombinant Antibody (CBFYM-2802) (CBMAB-M2995-FY)

Name: Mouse Anti-MUC2 (AA 5081-5179) Recombinant Antibody (CBFYM-2802)
SKU: CBMAB-M2995-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2802

Application

ELISA

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: TTEVSYAGCT KTVLMNHCSG SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE SCQCQDTVCG LPTGTSRRAR RSPRHLGSG

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 5081-5179

More Infomation

Target

Full Name

Mucin 2, Oligomeric Mucus/Gel-Forming

Introduction

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.

Entrez Gene ID

4583

UniProt ID

Q02817

Alternative Names

Mucin 2, Oligomeric Mucus/Gel-Forming; Mucin 2, Intestinal/Tracheal; MUC-2; SMUC; Intestinal Mucin-2; Mucin-2; MLP

Function

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Biological Process

Maintenance of gastrointestinal epithelium Source: UniProtKB

Cellular Location

Secreted
Note: In the intestine, secreted into the inner and outer mucus layers.

PTM

O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Leon-Coria, A., Kumar, M., Workentine, M., Moreau, F., Surette, M., & Chadee, K. (2021). Muc2 mucin and nonmucin microbiota confer distinct innate host defense in disease susceptibility and colonic injury. Cellular and Molecular Gastroenterology and Hepatology, 11(1), 77-98.

Yao, D., Dai, W., Dong, M., Dai, C., & Wu, S. (2021). MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis. EBioMedicine, 74.

Liu, Y., Yu, X., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020). The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression. International Journal of Biological Macromolecules, 164, 884-891.

Borisova, M. A., Achasova, K. M., Morozova, K. N., Andreyeva, E. N., Litvinova, E. A., Ogienko, A. A., ... & Kozhevnikova, E. N. (2020). Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium. Scientific reports, 10(1), 21135.

Cornick, S., Kumar, M., Moreau, F., Gaisano, H., & Chadee, K. (2019). VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis. Nature communications, 10(1), 4306.

Astashchanka, A., Shroka, T. M., & Jacobsen, B. M. (2019). Mucin 2 (MUC2) modulates the aggressiveness of breast cancer. Breast cancer research and treatment, 173, 289-299.

Bademler, S., Zirtiloglu, A., Sari, M., Ucuncu, M. Z., Dogru, E. B., & Karabulut, S. (2019). Clinical significance of serum membrane-bound mucin-2 levels in breast cancer. Biomolecules, 9(2), 40.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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