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Human Anti-MXRA8 Recombinant Antibody (2H2G12A) (CBMAB-M3057-FY)

This product is human antibody that recognizes MXRA8. The antibody 2H2G12A can be used for immunoassay techniques such as: FC.
See all MXRA8 antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
2H2G12A
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MATRIX REMODELING ASSOCIATED 8
Introduction
MXRA8 is a Protein Coding gene.
Entrez Gene ID
54587
UniProt ID
Q9BRK3
Alternative Names
Matrix Remodeling Associated 8; Limitrin; Matrix-Remodelling Associated 8; Matrix Remodeling-Associated Protein 8; Matrix-Remodeling-Associated Protein 8; ASP3
Function
Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276).

Mediates heterophilic cell-cell interactions in vitro (By similarity).

Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity).

Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity).

Stimulates formation of primary cilia in chondrocytes (By similarity).

Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity).

Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276).

Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276).

Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276).

May play a role in the maturation and maintenance of the blood-brain barrier (By similarity).

(Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.
Biological Process
Cell adhesion Source: UniProtKB-KW
Establishment of glial blood-brain barrier Source: CAFA
Cellular Location
Cytoplasm
Nucleus
Plasma membrane
Cell membrane
cilium membrane
Other locations
tight junction
Note: Primarily localizes to the cell membrane (PubMed:23386276). Detected in the cilium of primary chondrocytes (By similarity). Highly expressed at areas of cell-cell contact and may localize to tight junctions (By similarity). Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction (PubMed:23386276).
Topology
Extracellular: 20-341
Helical: 342-362
Cytoplasmic: 363-442

Zimmerman, O., Zimmerman, M. I., Raju, S., Nelson, C. A., Errico, J. M., Madden, E. A., ... & Diamond, M. S. (2023). Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8. Cell, 186(22), 4818-4833.

Simpson, K. E., Staikos, C. A., Watson, K. L., & Moorehead, R. A. (2023). Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis. International Journal of Molecular Sciences, 24(18), 13730.

Ng, W. H., Ling, Z. L., Kueh, A. J., Herold, M. J., West, N. P., King, N. J., ... & Liu, X. (2023). Role of MXRA8 in Ross River Virus Disease Pathogenesis. Mbio, 14(2), e00588-23.

Feng, F., Bouma, E. M., Hu, G., Zhu, Y., Yu, Y., Smit, J. M., ... & Zhang, R. (2023). Colocalization of Chikungunya Virus with Its Receptor MXRA8 during Cell Attachment, Internalization, and Membrane Fusion. Journal of Virology, 97(5), e01557-22.

Yin, P., & Kielian, M. (2021). BHK-21 cell clones differ in chikungunya virus infection and MXRA8 receptor expression. Viruses, 13(6), 949.

Powell, L. A., Miller, A., Fox, J. M., Kose, N., Klose, T., Kim, A. S., ... & Crowe, J. E. (2020). Human mAbs broadly protect against arthritogenic alphaviruses by recognizing conserved elements of the Mxra8 receptor-binding site. Cell host & microbe, 28(5), 699-711.

Kim, A. S., Zimmerman, O., Fox, J. M., Nelson, C. A., Basore, K., Zhang, R., ... & Diamond, M. S. (2020). An evolutionary insertion in the Mxra8 receptor-binding site confers resistance to alphavirus infection and pathogenesis. Cell host & microbe, 27(3), 428-440.

Basore, K., Kim, A. S., Nelson, C. A., Zhang, R., Smith, B. K., Uranga, C., ... & Fremont, D. H. (2019). Cryo-EM structure of chikungunya virus in complex with the Mxra8 receptor. Cell, 177(7), 1725-1737.

Zhang, R., Earnest, J. T., Kim, A. S., Winkler, E. S., Desai, P., Adams, L. J., ... & Diamond, M. S. (2019). Expression of the Mxra8 receptor promotes alphavirus infection and pathogenesis in mice and Drosophila. Cell reports, 28(10), 2647-2658.

Song, H., Zhao, Z., Chai, Y., Jin, X., Li, C., Yuan, F., ... & Gao, G. F. (2019). Molecular basis of arthritogenic alphavirus receptor MXRA8 binding to chikungunya virus envelope protein. Cell, 177(7), 1714-1724.

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For research use only. Not intended for any clinical use.

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