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Mouse Anti-MYBL1 (AA 625-734) Recombinant Antibody (CBFYM-2870) (CBMAB-M3064-FY)

This product is mouse antibody that recognizes MYBL1. The antibody CBFYM-2870 can be used for immunoassay techniques such as: ELISA, WB.
See all MYBL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2870
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 625-734

Target

Full Name
v-myb myeloblastosis viral oncogene homolog (avian)-like 1
Introduction
MYBL1 is a Protein Coding gene. Diseases associated with MYBL1 include Burkitt Lymphoma and Breast Adenoid Cystic Carcinoma. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology annotations related to this gene include chromatin binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYB.
Entrez Gene ID
4603
UniProt ID
P10243
Alternative Names
MYB Proto-Oncogene Like 1; V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1; Myb-Like Protein 1; A-MYB; AMYB; Myb-Related Protein A
Function
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850).

Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity).

The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).

Transcriptional activator of SOX30 (By similarity).
Biological Process
Cell differentiation Source: UniProtKB-KW
Male meiosis I Source: UniProtKB
Mitotic cell cycle Source: GO_Central
Negative regulation of transposition Source: UniProtKB
piRNA biosynthetic process Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: GO_Central
Spermatogenesis Source: UniProtKB
Cellular Location
Nucleus

Säflund, M., & Özata, D. M. (2023). The MYBL1/TCFL5 transcription network: two collaborative factors with central role in male meiosis. Biochemical Society Transactions, 51(6), 2163-2172.

Ueda, K., Murase, T., Kawakita, D., Nagao, T., Kusafuka, K., Nakaguro, M., ... & Inagaki, H. (2023). The landscape of MYB/MYBL1-and peri-MYB/MYBL1-associated rearrangements in adenoid cystic carcinoma. Modern Pathology, 36(10), 100274.

Persson, M., Andersson, M. K., Mitani, Y., Brandwein-Weber, M. S., Frierson Jr, H. F., Moskaluk, C., ... & Stenman, G. (2022). Rearrangements, expression, and clinical significance of myb and Mybl1 in adenoid cystic carcinoma: A multi-institutional study. Cancers, 14(15), 3691.

Zhu, J., Wu, Y., Yu, Y., Li, Y., Shen, J., & Zhang, R. (2022). MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma. Cell Death & Disease, 13(8), 727.

Xu, J., Wang, B., & Zhang, D. (2022). LncRNA ENSMUST00000171502 induced by HIF-1α ameliorates ischemic acute kidney injury via targeting the miR-130b-3p/Mybl-1 axis. Cells, 11(23), 3747.

Nikolaus, M., Koch, A., Stenzel, W., Elezkurtaj, S., Sahm, F., Tietze, A., ... & Knierim, E. (2022). Atypical NMDA receptor expression in a diffuse astrocytoma, MYB-or MYBL1-altered as a trigger for autoimmune encephalitis. Acta Neuropathologica, 144(2), 385-389.

Wefers, A. K., Stichel, D., Schrimpf, D., Coras, R., Pages, M., Tauziède-Espariat, A., ... & Capper, D. (2020). Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta neuropathologica, 139, 193-209.

Ellison, D. W., Hawkins, C., Jones, D. T., Onar-Thomas, A., Pfister, S. M., Reifenberger, G., & Louis, D. N. (2019). cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF V600E mutation. Acta neuropathologica, 137, 683-687.

Chiang, J., Harreld, J. H., Tinkle, C. L., Moreira, D. C., Li, X., Acharya, S., ... & Ellison, D. W. (2019). A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration. Acta neuropathologica, 138, 1091-1092.

Pei, J., Flieder, D. B., Patchefsky, A., Talarchek, J. N., Cooper, H. S., Testa, J. R., & Wei, S. (2019). Detecting MYB and MYBL1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted RNA-sequencing. Modern Pathology, 32(10), 1416-1420.

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For research use only. Not intended for any clinical use.

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