MYBL1

MYBL1 (MYB Proto-Oncogene Like 1) is a Protein Coding gene. Diseases associated with MYBL1 include Burkitt Lymphoma and Breast Adenoid Cystic Carcinoma. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYB.

Full Name

v-myb myeloblastosis viral oncogene homolog (avian)-like 1

Function

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850).

Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity).

The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).

Transcriptional activator of SOX30 (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Male meiosis I Source: UniProtKB
Mitotic cell cycle Source: GO_Central
Negative regulation of transposition Source: UniProtKB
piRNA biosynthetic process Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: GO_Central
Spermatogenesis Source: UniProtKB

Cellular Location

Nucleus