Mouse Anti-MYH14 Recombinant Antibody (CBFYM-2927) (CBMAB-M3122-FY)

Name: Mouse Anti-MYH14 Recombinant Antibody (CBFYM-2927)
SKU: CBMAB-M3122-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2927

Application

IHC-Fr, IHC-P

Immunogen

Myosin isolated from rabbit skeletal muscle

Specificity

Human, Mouse, Dog, Rat, Rabbit

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Myosin Heavy Chain 14

Introduction

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	79784
Mouse	71960
Rat	308572
Dog	100688336

UniProt ID

Human	Q7Z406
Mouse	Q6URW6
Rat	F1LNF0
Dog	A0A5F4D5L6

Alternative Names

Myosin Heavy Chain 14; Myosin, Heavy Chain 14, Non-Muscle; Myosin Heavy Chain, Non-Muscle IIc; Non-Muscle Myosin Heavy Chain IIc; Myosin, Heavy Polypeptide 14; NMHC II-C; Nonmuscle Myosin Heavy Chain II-C; MYH14 Variant Protein; NMHC-II-C; Myosin-14

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.

Biological Process

Actin filament-based movement Source: Ensembl
Actomyosin structure organization Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Neuronal action potential Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Skeletal muscle contraction Source: UniProtKB
Skeletal muscle tissue development Source: UniProtKB
Vocalization behavior Source: UniProtKB

Cellular Location

Cytoskeleton
actomyosin
myosin II complex
stress fiber
Cytosol
Extracellular region
extracellular exosome
Other locations
brush border
growth cone
membrane
myosin II filament

Involvement in disease

Deafness, autosomal dominant, 4A (DFNA4A):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH):
A complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.

Lv, Y., Chen, J., Hu, J., Qian, Y., Kong, Y., & Fu, L. (2020). Nonmuscle myosin heavy chain ⅡA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway. Frontiers in Pharmacology, 11, 598592.

López-Unzu, M. A., Durán, A. C., Soto-Navarrete, M. T., Sans-Coma, V., & Fernández, B. (2019). Differential expression of myosin heavy chain isoforms in cardiac segments of gnathostome vertebrates and its evolutionary implications. Frontiers in zoology, 16(1), 1-15.

Reiser, P. J. (2019). Current understanding of conventional and novel co-expression patterns of mammalian sarcomeric myosin heavy chains and light chains. Archives of biochemistry and biophysics, 662, 129-133.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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