MYH14
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
Myosin Heavy Chain 14
Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Biological Process
Actin filament-based movement Source: Ensembl
Actomyosin structure organization Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Neuronal action potential Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Skeletal muscle contraction Source: UniProtKB
Skeletal muscle tissue development Source: UniProtKB
Vocalization behavior Source: UniProtKB
Actomyosin structure organization Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Neuronal action potential Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Skeletal muscle contraction Source: UniProtKB
Skeletal muscle tissue development Source: UniProtKB
Vocalization behavior Source: UniProtKB
Cellular Location
Cytoskeleton
actomyosin
myosin II complex
stress fiber
Cytosol
Extracellular region
extracellular exosome
Other locations
brush border
growth cone
membrane
myosin II filament
actomyosin
myosin II complex
stress fiber
Cytosol
Extracellular region
extracellular exosome
Other locations
brush border
growth cone
membrane
myosin II filament
Involvement in disease
Deafness, autosomal dominant, 4A (DFNA4A):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH):
A complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH):
A complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
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Anti-MYH14 antibodies
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CompareTarget: MYH14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D4A7
Application*: WB, IF (IC)
Target: MYH14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Rabbit
Clone: CBFYM-2930
Application*: P, E, IF
Target: MYH14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Rabbit
Clone: CBFYM-2929
Application*: WB, P
Target: MYH14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYM-2928
Application*: WB, IF
Target: MYH14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog, Rat, Rabbit
Clone: CBFYM-2927
Application*: C, P
Target: MYH14
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Dog, Mouse, Rat, Rodent
Clone: CBFYM-2926
Application*: WB, IP
Target: MYH14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2925
Application*: WB, IH
Target: MYH14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2924
Application*: E, WB, IH, IP
Target: MYH14
Host: Mouse
Antibody Isotype: IgG
Specificity: Fruit fly, Human, Mouse, Rabbit, Rat
Clone: CBFYM-2923
Application*: WB, IH
Target: MYH14
Host: Human
Specificity: Cattle, Chicken, Dog, Human, Rat, Mouse
Clone: CBFYM-2922
Application*: C, E, WB
Target: MYH14
Host: Mouse
Specificity: Chicken, Human, Mouse, Rabbit
Clone: CBFYM-2921
Application*: IH, WB
Target: MYH14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0768
Application*: IH
Target: MYH14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0361
Application*: F
Target: MYH14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-0068
Application*: WB, E, IH, IF, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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