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Mouse Anti-MYLK2 Recombinant Antibody (2G1) (CBMAB-A5735-LY)

The product is antibody recognizes MYLK2. The antibody 2G1 immunoassay techniques such as: WB, ELISA.
See all MYLK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MYLK2 (NP_149109, 161 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
myosin light chain kinase 2
Introduction
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq]
Entrez Gene ID
85366
UniProt ID
Q9H1R3
Alternative Names
KMLC; MLCK; MLCK2; skMLCK
Function
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Cardiac muscle tissue morphogenesis Source: BHF-UCL
Neuromuscular synaptic transmission Source: Ensembl
Peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Regulation of muscle filament sliding Source: BHF-UCL
Skeletal muscle cell differentiation Source: UniProtKB
Skeletal muscle satellite cell differentiation Source: Ensembl
Striated muscle contraction Source: BHF-UCL
Cellular Location
Cytoplasm
Note: Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Involvement in disease
Cardiomyopathy, familial hypertrophic (CMH):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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