Human Recombinant MYLK2, Active protein, His Tag (V2LY-0526-LY5674)

Name: Human Recombinant MYLK2, Active protein, His Tag
SKU: V2LY-0526-LY5674
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant MYLK2, Active protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 74 kDa.

Molecule Mass

74 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

myosin light chain kinase 2

Function

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.

Biological Process

Cardiac muscle contraction Source: BHF-UCL
Cardiac muscle tissue morphogenesis Source: BHF-UCL
Neuromuscular synaptic transmission Source: Ensembl
Peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Regulation of muscle filament sliding Source: BHF-UCL
Skeletal muscle cell differentiation Source: UniProtKB
Skeletal muscle satellite cell differentiation Source: Ensembl
Striated muscle contraction Source: BHF-UCL

Cellular Location

Cytoplasm
Note: Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.

Involvement in disease

Cardiomyopathy, familial hypertrophic (CMH):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Qin, X., Li, P., Qu, H. Q., Liu, Y., Xia, Y., Chen, S., ... & Zhuang, J. (2021). FLNC and MYLK2 gene mutations in a Chinese family with different phenotypes of cardiomyopathy. International Heart Journal, 62(1), 127-134.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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