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Mouse Anti-MYLK2 (AA 161-260) Recombinant Antibody (CBFYM-2973) (CBMAB-M3168-FY)

This product is mouse antibody that recognizes MYLK2. The antibody CBFYM-2973 can be used for immunoassay techniques such as: ELISA, siRNA, WB.
See all MYLK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2973
Antibody Isotype
IgG1, k
Application
ELISA, siRNA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: KLLAKKPPSE ASELTFEGVP MTHSPTDPRP AKAEEGKNIL AESQKEVGEK TPGQAGQAKM QGDTSRGIEF QAVPSEKSEV GQALCLTARE EDCFQILDDC
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 161-260

Target

Full Name
myosin light chain kinase 2
Introduction
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
Entrez Gene ID
85366
UniProt ID
Q9H1R3
Alternative Names
Myosin Light Chain Kinase 2; Myosin Light Chain Kinase 2, Skeletal Muscle; EC 2.7.11.18; MLCK2; Myosin Light Chain Kinase 2, Skeletal/Cardiac Muscle; Skeletal Muscle Myosin Light Chain Kinase
Function
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Cardiac muscle tissue morphogenesis Source: BHF-UCL
Neuromuscular synaptic transmission Source: Ensembl
Peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Regulation of muscle filament sliding Source: BHF-UCL
Skeletal muscle cell differentiation Source: UniProtKB
Skeletal muscle satellite cell differentiation Source: Ensembl
Striated muscle contraction Source: BHF-UCL
Cellular Location
Cytoplasm
Note: Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Involvement in disease
Cardiomyopathy, familial hypertrophic (CMH):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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