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Mouse Anti-MYO3A Recombinant Antibody (6D10) (CBMAB-A5742-LY)

The product is antibody recognizes MYO3A. The antibody 6D10 immunoassay techniques such as: WB, ELISA.
See all MYO3A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6D10
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
MYO3A (NP_059129, 1400 a.a. ~ 1490 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
myosin IIIA
Introduction
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq]
Entrez Gene ID
53904
UniProt ID
Q8NEV4
Alternative Names
DFNB30
Function
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315).

Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity).
Biological Process
Cochlea morphogenesis Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Response to stimulus Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Visual perception Source: UniProtKB-KW
Cellular Location
Cytoskeleton
Cytoplasm
Other locations
filopodium tip
stereocilium
Note: Increased localization at the filodium tip seen in the presence of MORN4.
Involvement in disease
Deafness, autosomal recessive, 30 (DFNB30):
A form of non-syndromic deafness characterized by bilateral progressive hearing loss, which first affects the high frequencies. Hearing loss begins in the second decade, and by age 50 is severe in high and middle frequencies and moderate at low frequencies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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