Human Recombinant MYO3A, Active protein, GST Tag (V2LY-0526-LY5677)

Name: Human Recombinant MYO3A, Active protein, GST Tag
SKU: V2LY-0526-LY5677
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant MYO3A, Active protein, GST Tag consist of Amino Acid: 1-434 and predicts a molecular mass of 76 kDa.

Molecule Mass

76 kDa

Sequence

Amino Acid: 1-434

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

myosin IIIA

Function

Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315).

Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity).

Biological Process

Cochlea morphogenesis Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Response to stimulus Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Visual perception Source: UniProtKB-KW

Cellular Location

Cytoskeleton
Cytoplasm
Other locations
filopodium tip
stereocilium
Note: Increased localization at the filodium tip seen in the presence of MORN4.

Involvement in disease

Deafness, autosomal recessive, 30 (DFNB30):
A form of non-syndromic deafness characterized by bilateral progressive hearing loss, which first affects the high frequencies. Hearing loss begins in the second decade, and by age 50 is severe in high and middle frequencies and moderate at low frequencies.

Gunther, L. K., Cirilo Jr, J. A., Desetty, R., & Yengo, C. M. (2022). Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism. Molecular biology of the cell, 33(1), ar5.

Bueno, A. S., Nunes, K., Dias, A. M., Alves, L. U., Mendes, B. C., Sampaio-Silva, J., ... & Mingroni-Netto, R. C. (2022). Frequency and origin of the c. 2090T> G p.(Leu697Trp) MYO3A variant associated with autosomal dominant hearing loss. European Journal of Human Genetics, 30(1), 13-21.

Doll, J., Hofrichter, M. A., Bahena, P., Heihoff, A., Segebarth, D., Müller, T., ... & Vona, B. (2020). A novel missense variant in MYO3A is associated with autosomal dominant high‐frequency hearing loss in a German family. Molecular Genetics & Genomic Medicine, 8(8), e1343.

Wonkam, A., Manyisa, N., Bope, C. D., Dandara, C., & Chimusa, E. R. (2020). Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon. Human molecular genetics, 29(23), 3729-3743.

Li, J., Liu, H., Raval, M. H., Wan, J., Yengo, C. M., Liu, W., & Zhang, M. (2019). Structure of the MORN4/Myo3a tail complex reveals MORN repeats as protein binding modules. Structure, 27(9), 1366-1374.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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