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Mouse Anti-MYOF Recombinant Antibody (CBFYM-3007) (CBMAB-M3202-FY)

This product is mouse antibody that recognizes MYOF. The antibody CBFYM-3007 can be used for immunoassay techniques such as: IHC, WB.
See all MYOF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3007
Antibody Isotype
IgG2a, k
Application
IHC, WB

Basic Information

Immunogen
Human FER1L3 fusion protein
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYOFERLIN
Introduction
Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.
Entrez Gene ID
26509
UniProt ID
Q9NZM1
Alternative Names
Myoferlin; Fer-1-Like Family Member 3; Fer-1-Like Protein 3; FER1L3; Fer-1 (C.Elegans)-Like 3 (Myoferlin); Fer-1-Like 3, Myoferlin (C. Elegans); Fer-1-Like 3, Myoferlin; KIAA1207
Function
Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).
Biological Process
Blood circulation Source: ProtInc
Membrane fusion Source: GO_Central
Muscle contraction Source: ProtInc
Myoblast fusion Source: InterPro
Plasma membrane organization Source: GO_Central
Plasma membrane repair Source: UniProtKB
T-tubule organization Source: GO_Central
Cellular Location
Nucleus
Nucleus membrane
Plasma membrane
Cell membrane
Other locations
Cytoplasmic vesicle membrane
Note: Concentrated at the membrane sites of both myoblast-myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels (By similarity). Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures.
Involvement in disease
Angioedema, hereditary, 7 (HAE7):
A form of angioedema, a disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. HAE7 is an autosomal dominant form characterized by onset of recurrent swelling of the face, lips, and oral mucosa in the second decade.
Topology
Cytoplasmic: 1-2025
Helical: 2026-2046
Extracellular: 2047-2061

Zhang, Y., Liu, W., Yuan, W., Cai, Z., Ye, G., Zheng, G., ... & Wang, P. (2022). Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. Cellular and Molecular Life Sciences, 79(9), 488.

Shi, H., Cheng, Y., Shi, Q., Liu, W., Yang, X., Wang, S., ... & Fang, H. (2022). Myoferlin disturbs redox equilibrium to accelerate gastric cancer migration. Frontiers in Oncology, 12, 905230.

Barefield, D. Y., Sell, J. J., Tahtah, I., Kearns, S. D., McNally, E. M., & Demonbreun, A. R. (2021). Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle. Scientific reports, 11(1), 15865.

Pi, R., Chen, Y., Du, Y., & Dong, S. (2021). Comprehensive analysis of myoferlin in human pancreatic cancer via bioinformatics. BioMed Research International, 2021.

Gupta, S., Yano, J., Mercier, V., Htwe, H. H., Shin, H. R., Rademaker, G., ... & Perera, R. M. (2021). Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. Nature cell biology, 23(3), 232-242.

Nozato, Y., Takami, Y., Yamamoto, K., Nagasawa, M., Nozato, S., Imaizumi, Y., ... & Rakugi, H. (2020). Novel properties of myoferlin in glucose metabolism via pathways involving modulation of adipose functions. The FASEB Journal, 34(2), 2792-2811.

Gu, H., Peng, Y., & Chen, Y. (2020). An emerging therapeutic approach by targeting myoferlin (MYOF) for malignant tumors. Current Topics in Medicinal Chemistry, 20(17), 1509-1515.

Cox, A., Zhao, C., Tolkach, Y., Nettersheim, D., Schmidt, D., Kristiansen, G., ... & Ellinger, J. (2020). Knockdown of myoferlin suppresses migration and invasion in clear-cell renal-cell carcinoma. Anticancer Research, 40(6), 3119-3128.

Han, S., Cui, C., He, H., Shen, X., Chen, Y., Wang, Y., ... & Yin, H. (2019). Myoferlin regulates Wnt/β-catenin signaling-mediated skeletal muscle development by stabilizing dishevelled-2 against autophagy. International Journal of Molecular Sciences, 20(20), 5130.

Dong, Y., Kang, H., Liu, H., Wang, J., Guo, Q., Song, C., ... & Li, F. (2019). Myoferlin, a membrane protein with emerging oncogenic roles. BioMed Research International, 2019.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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