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Mouse Anti-NADK Recombinant Antibody (5F4) (CBMAB-N1062-WJ)

This product is a Mouse antibody that recognizes NADK. The antibody 5F4 can be used for immunoassay techniques such as: ELISA, WB.
See all NADK antibodies
Published Data
Fig.1 Localization of human NADK constructs to the cytoplasm.
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Fig.2 Modulation of NAD kinase expression in HEK293 cells.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
5F4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NAD Kinase
Introduction
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human65220
Mouse192185
UniProt ID
HumanO95544
MouseP58058
Alternative Names
NAD Kinase; Poly(P)/ATP NAD Kinase; EC 2.7.1.23; DJ283E3.1; EC 2.7.1;
Biological Process
ATP metabolic process Source: UniProtKB
NAD metabolic process Source: InterPro
NADP biosynthetic process Source: GO_Central
Phosphorylation Source: UniProtKB
Cellular Location
Cytosol

Oka, S. I., Titus, A. S., Zablocki, D., & Sadoshima, J. (2023). Molecular properties and regulation of NAD+ kinase (NADK). Redox Biology, 59, 102561.

Zhang, R., & Zhang, K. (2023). Mitochondrial NAD kinase in health and disease. Redox Biology, 60, 102613.

Du, J., Estrella, M., Solorio-Kirpichyan, K., Jeffrey, P. D., & Korennykh, A. (2022). Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria. Proceedings of the National Academy of Sciences, 119(26), e2200923119.

Kim, H., Fu, Z., Yang, Z., Song, Z., Yumnamcha, T., Sun, S., ... & Zhang, K. (2022). The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. Molecular Metabolism, 64, 101562.

Xu, M., Ding, L., Liang, J., Yang, X., Liu, Y., Wang, Y., ... & Huang, X. (2021). NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis. Cell Reports, 37(13).

Wang, X., Li, B. B., Ma, T. T., Sun, L. Y., Tai, L., Hu, C. H., ... & Chen, K. M. (2020). The NAD kinase OsNADK1 affects the intracellular redox balance and enhances the tolerance of rice to drought. BMC plant biology, 20(1), 1-19.

Rabani, R., Cossette, C., Graham, F., & Powell, W. S. (2020). Protein kinase C activates NAD kinase in human neutrophils. Free Radical Biology and Medicine, 161, 50-59.

Ishikawa, Y., & Kawai-Yamada, M. (2019). Physiological significance of NAD kinases in cyanobacteria. Frontiers in Plant Science, 10, 847.

Hoxhaj, G., Ben-Sahra, I., Lockwood, S. E., Timson, R. C., Byles, V., Henning, G. T., ... & Manning, B. D. (2019). Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. Science, 363(6431), 1088-1092.

Tai, L., Li, B. B., Nie, X. M., Zhang, P. P., Hu, C. H., Zhang, L., ... & Chen, K. M. (2019). Calmodulin is the fundamental regulator of NADK-mediated NAD signaling in plants. Frontiers in Plant Science, 10, 681.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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