Mouse Anti-NANS Recombinant Antibody (1G6) (CBMAB-N0126-WJ)

Name: Mouse Anti-NANS Recombinant Antibody (1G6)
SKU: CBMAB-N0126-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1G6

Application

WB, ELISA

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

N-Acetylneuraminate Synthase

Introduction

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]

Entrez Gene ID

54187

UniProt ID

Q9NR45

Alternative Names

N-Acetylneuraminate Synthase; N-Acetylneuraminic Acid Synthase; N-Acetylneuraminic Acid Phosphate Synthase; N-Acetylneuraminate-9-Phosphate Synthase; Sialic Acid Synthase; SAS; Epididymis Secretory Protein Li 100;

Function

Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:10749855, PubMed:27213289).

Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (PubMed:10749855).

Biological Process

Carbohydrate biosynthetic process Source: InterPro
CMP-N-acetylneuraminate biosynthetic process Source: UniProtKB
Glycosylation Source: GO_Central

Cellular Location

Cytosol Source: Reactome
Extracellular region or secreted
Extracellular exosome Source: UniProtKB
Other locations
Cytoplasm

Involvement in disease

Spondyloepimetaphyseal dysplasia, Genevieve type (SEMDG):
An autosomal recessive disorder characterized by global developmental delay with infantile onset, mental retardation, skeletal dysplasia, and short stature. Skeletal findings include flat vertebral bodies with irregular vertebral plates, irregular and flared metaphyses with vertical striations, small and irregular epiphyses, premature carpal ossification and small carpal bones.

Bose, S., Purkait, D., Joseph, D., Nayak, V., & Subramanian, R. (2019). Structural and functional characterization of CMP-N-acetylneuraminate synthetase from Vibrio cholerae. Acta Crystallographica Section D: Structural Biology, 75(6), 564-577.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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