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Mouse Anti-NANS Recombinant Antibody (B-1) (CBMAB-N1141-WJ)

This product is a Mouse antibody that recognizes NANS. The antibody B-1 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NANS antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
B-1
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-Acetylneuraminate Synthase
Introduction
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human54187
Mouse94181
Rat298071
UniProt ID
HumanQ9NR45
MouseQ99J77
RatB1WC26
Alternative Names
N-Acetylneuraminate Synthase; N-Acetylneuraminic Acid Synthase; N-Acetylneuraminic Acid Phosphate Synthase; N-Acetylneuraminate-9-Phosphate Synthase; Sialic Acid Synthase; SAS; Epididymis Secretory Protein Li 100;
Function
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:10749855, PubMed:27213289).

Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (PubMed:10749855).
Biological Process
Carbohydrate biosynthetic process Source: InterPro
CMP-N-acetylneuraminate biosynthetic process Source: UniProtKB
Glycosylation Source: GO_Central
Cellular Location
Cytosol Source: Reactome
Extracellular region or secreted
Extracellular exosome Source: UniProtKB
Other locations
Cytoplasm
Involvement in disease
Spondyloepimetaphyseal dysplasia, Genevieve type (SEMDG):
An autosomal recessive disorder characterized by global developmental delay with infantile onset, mental retardation, skeletal dysplasia, and short stature. Skeletal findings include flat vertebral bodies with irregular vertebral plates, irregular and flared metaphyses with vertical striations, small and irregular epiphyses, premature carpal ossification and small carpal bones.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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