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Mouse Anti-NARG1 Recombinant Antibody (4A11) (CBMAB-A5789-LY)

The product is antibody recognizes NARG1. The antibody 4A11 immunoassay techniques such as: WB, ELISA.
See all NARG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
NARG1 (NP_476516.1, 764 a.a. ~ 862 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NMDA receptor regulated 1
Introduction
This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq]
Entrez Gene ID
Alternative Names
Ga19; NATH; TBDN100
Function
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062).

The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142).

Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548).

In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306).
Biological Process
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
N-terminal peptidyl-methionine acetylation Source: GO_Central
N-terminal protein amino acid acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein stabilization Source: UniProtKB
Cellular Location
Nucleus
Cytoplasm
Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 50, with behavioral abnormalities (MRD50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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