Mouse Anti-NARG1 Recombinant Antibody (4A11) (CBMAB-A5789-LY)

Name: Mouse Anti-NARG1 Recombinant Antibody (4A11)
SKU: CBMAB-A5789-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4A11

Application

WB, ELISA

Immunogen

NARG1 (NP_476516.1, 764 a.a. ~ 862 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

NMDA receptor regulated 1

Introduction

This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq]

Entrez Gene ID

80155

Alternative Names

Ga19; NATH; TBDN100

Function

Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062).

The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142).

Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548).

In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306).

Biological Process

Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
N-terminal peptidyl-methionine acetylation Source: GO_Central
N-terminal protein amino acid acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein stabilization Source: UniProtKB

Cellular Location

Nucleus
Cytoplasm
Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Involvement in disease

Intellectual developmental disorder, autosomal dominant 50, with behavioral abnormalities (MRD50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

PTM

Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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