NARG1

This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq]

Full Name

NMDA receptor regulated 1

Function

Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062).

The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142).

Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548).

In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306).

Biological Process

Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
N-terminal peptidyl-methionine acetylation Source: GO_Central
N-terminal protein amino acid acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein stabilization Source: UniProtKB

Cellular Location

Nucleus
Cytoplasm
Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Involvement in disease

Intellectual developmental disorder, autosomal dominant 50, with behavioral abnormalities (MRD50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

PTM

Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.