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Rabbit Anti-NAT1 Recombinant Antibody (CBWJN-1176) (CBMAB-N1216-WJ)

This product is a Rabbit antibody that recognizes NAT1. The antibody CBWJN-1176 can be used for immunoassay techniques such as: WB, FC, ICC.
See all NAT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJN-1176
Antibody Isotype
IgG
Application
WB, FC, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 49%, Glycerol 50%, BSA 0.05%
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-Acetyltransferase 1
Introduction
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Entrez Gene ID
9
UniProt ID
P18440
Alternative Names
N-Acetyltransferase 1; N-Acetyltransferase 1 (Arylamine N-Acetyltransferase); Monomorphic Arylamine N-Acetyltransferase; Arylamine N-Acetyltransferase 1; N-Acetyltransferase Type 1; Arylamide Acetylase 1;
Function
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Biological Process
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cytoplasm

Salazar-González, R. A., Doll, M. A., & Hein, D. W. (2022). Arylamine N-acetyltransferase 1 activity is regulated by the protein acetylation status. Frontiers in Pharmacology, 13, 797469.

Carlisle, S. M., Trainor, P. J., Doll, M. A., & Hein, D. W. (2022). Human arylamine N-acetyltransferase 1 (NAT1) knockout in MDA-MB-231 breast cancer cell lines leads to transcription of NAT2. Frontiers in Pharmacology, 12, 803254.

Habil, M. R., Doll, M. A., & Hein, D. W. (2022). Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1* 14B variant. Frontiers in Pharmacology, 13, 931323.

Hein, D. W., Doll, M. A., & Habil, M. R. (2022). Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens. Frontiers in Pharmacology, 13, 821133.

Venkatesan, G., Lim, Z. C., Karkhanis, A. V., Neupane, Y. R., Dancik, Y., Huang, C., ... & Pastorin, G. (2021). Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1). Archives of Toxicology, 1-13.

Butcher, N. J., Burow, R., & Minchin, R. F. (2020). Modulation of human arylamine N-Acetyltransferase 1 activity by lysine acetylation: Role of p300/CREB-binding protein and Sirtuins 1 and 2. Molecular pharmacology, 98(2), 88-95.

Shi, C., Xie, L. Y., Tang, Y. P., Long, L., Li, J. L., Hu, B. L., & Li, K. Z. (2019). Hypermethylation of N-acetyltransferase 1 is a prognostic biomarker in colon adenocarcinoma. Frontiers in Genetics, 10, 1097.

Stepp, M. W., Salazar-González, R. A., Hong, K. U., Doll, M. A., & Hein, D. W. (2019). N-acetyltransferase 1 knockout elevates acetyl coenzyme A levels and reduces anchorage-independent growth in human breast cancer cell lines. Journal of oncology, 2019.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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