Mouse Anti-NAT6 Recombinant Antibody (CBXF-1454) (CBMAB-F4166-CQ)

Name: Mouse Anti-NAT6 Recombinant Antibody (CBXF-1454)
SKU: CBMAB-F4166-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1454

Application

ELISA, ICC, IF, WB

Immunogen

Recombinant protein corresponding to aa1-308 of human FUS2 expressed in E. coli (NP_036323)

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 10% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

N-acetyltransferase 6

Introduction

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon.

Entrez Gene ID

24142

UniProt ID

Q93015

Alternative Names

N-Acetyltransferase 6; Protein Fusion-2; FUS2; N-Acetyltransferase 6 (GCN5-Related); Protein Fus-2; EC 2.3.1.-; FUS-2;

Function

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253).

N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253).

In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253).

In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307).

May act as a tumor suppressor (PubMed:10644992).

Biological Process

Actin modification Source: UniProtKB
N-terminal peptidyl-aspartic acid acetylation Source: UniProtKB
N-terminal peptidyl-glutamic acid acetylation Source: UniProtKB
Protein acetylation Source: UniProtKB
Regulation of actin polymerization or depolymerization Source: UniProtKB

Cellular Location

Cytosol

Yang, H., Fan, T., Xun, M., Wu, B., Guo, S., Li, X., ... & Wang, H. (2024). N-terminal acetyltransferase 6 facilitates enterovirus 71 replication by regulating PI4KB expression and replication organelle biogenesis. Journal of Virology, e01749-23.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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