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Mouse Anti-NAT6 Recombinant Antibody (CBXF-3722) (CBMAB-F0092-CQ)

This product is a mouse antibody that recognizes NAT6. The antibody CBXF-3722 can be used for immunoassay techniques such as: WB, ELISA, IF.
See all NAT6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3722
Antibody Isotype
IgG2b, κ
Application
WB, ELISA, IF

Basic Information

Immunogen
Recombinant FUS2 (1-308aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-acetyltransferase 6
Introduction
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon.
Entrez Gene ID
24142
UniProt ID
Q93015
Alternative Names
N-Acetyltransferase 6; Protein Fusion-2; FUS2; N-Acetyltransferase 6 (GCN5-Related); Protein Fus-2; EC 2.3.1.-; FUS-2;
Function
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253).

N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253).

In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253).

In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307).

May act as a tumor suppressor (PubMed:10644992).
Biological Process
Actin modification Source: UniProtKB
N-terminal peptidyl-aspartic acid acetylation Source: UniProtKB
N-terminal peptidyl-glutamic acid acetylation Source: UniProtKB
Protein acetylation Source: UniProtKB
Regulation of actin polymerization or depolymerization Source: UniProtKB
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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