Mouse Anti-NAV1 Recombinant Antibody (G-12) (CBMAB-N1233-WJ)

Name: Mouse Anti-NAV1 Recombinant Antibody (G-12)
SKU: CBMAB-N1233-WJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

G-12

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

neuron navigator 1

Introduction

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Entrez Gene ID

89796

UniProt ID

Q8NEY1

Alternative Names

Neuron Navigator 1; Pore Membrane And/Or Filament Interacting Like Protein 3; Unc-53 Homolog 1; STEERIN1; UNC53H1; POMFIL3;

Function

May be involved in neuronal migration.

Biological Process

Microtubule bundle formation Source: GO_Central
Nervous system development Source: GO_Central
Neuron migration Source: GO_Central

Cellular Location

Cytoskeleton
Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity).

More Infomation

References

Bagley, J. R., Tan, Y., Zhu, W., Cheng, Z., Takeda, S., Fang, Z., ... & Peltz, G. (2023). Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice. Communications Biology, 6(1), 1053.

Powers, R. M., Hevner, R. F., & Halpain, S. (2023). The Neuron Navigators: Structure, function, and evolutionary history. Frontiers in Molecular Neuroscience, 15, 1099554.

Bagley, J. R., Tan, Y., Zhu, W., Cheng, Z., Takeda, S., Fang, Z., ... & Peltz, G. (2022). Neuron Navigator 1 Regulates Learning, Memory, and the Response to Multiple Potentially Addictive Drugs. bioRxiv, 2022-11.

Powers, R. M., Daza, R., Koehler, A. E., Courchet, J., Calabrese, B., Hevner, R. F., & Halpain, S. (2022). Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1. Molecular biology of the cell, 33(7), ar64.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rat Anti-NAV1 Recombinant Antibody (KT124)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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