NAV1

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants.

neuron navigator 1

May be involved in neuronal migration.

Microtubule bundle formation Source: GO_Central
Nervous system development Source: GO_Central
Neuron migration Source: GO_Central

Cytoskeleton
Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity).