Mouse Anti-NCAM1 Recombinant Antibody (CBYY-C0057) (CBMAB-C0177-YY)

This product is mouse antibody that recognizes NCAM1. The antibody CBYY-C0057 can be used for immunoassay techniques such as: FC
See all NCAM1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C0057

Antibody Isotype

IgG1, κ

Application

Basic Information

Immunogen

KG1a cells

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Neural Cell Adhesion Molecule 1

Entrez Gene ID

4684

UniProt ID

P13591

Function

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

(Microbial infection) Acts as a receptor for rabies virus.

(Microbial infection) Acts as a receptor for Zika virus.

Biological Process

Cell adhesion Source: ProtInc
Commissural neuron axon guidance Source: ARUK-UCL
Regulation of semaphorin-plexin signaling pathway Source: ARUK-UCL

Cellular Location

Isoform 1&2&3&4: Cell membrane
Isoform 5&6: Secreted

Topology

Extracellular: 20-718
Helical: 719-739
Cytoplasmic: 740-858

References

Kim, W., Watanabe, H., Lomoio, S., & Tesco, G. (2021). Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. Journal of Biological Chemistry, 296.

Caza, T. N., Hassen, S. I., Kuperman, M., Sharma, S. G., Dvanajscak, Z., Arthur, J., ... & Larsen, C. P. (2021). Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kidney international, 100(1), 171-181.

Vukojevic, V., Mastrandreas, P., Arnold, A., Peter, F., Kolassa, I. T., Wilker, S., ... & Stetak, A. (2020). Evolutionary conserved role of neural cell adhesion molecule-1 in memory. Translational psychiatry, 10(1), 217.

Jesudas, B. R., Nandeesha, H., Menon, V., & Allimuthu, P. (2020). Relationship of elevated neural cell adhesion molecule 1 with interleukin-10 and disease severity in bipolar disorder. Asian Journal of Psychiatry, 47, 101849.

Kim, Y. H., Kim, Y. H., Shin, Y. K., Jo, Y. R., Park, D. K., Song, M. Y., ... & Park, H. T. (2019). p75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies. Annals of Clinical and Translational Neurology, 6(7), 1292-1301.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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