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  • Rabbit Anti-NCAM1 Recombinant Antibody (CBYY-C1507)

Rabbit Anti-NCAM1 Recombinant Antibody (CBYY-C1507) (CBMAB-C2945-YY)

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Basic Information

Host Animal
Rabbit
Clone
CBYY-C1507
Application
FC, ICC, IF, WB
Immunogen
Recombinant protein corresponding to amino acids 20–170 of human NCAM
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.5 mg/mL
Preservative
PBS
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Neural Cell Adhesion Molecule 1
Entrez Gene ID
Human4684
Mouse17967
Rat24586
UniProt ID
HumanP13591
MouseP13595
RatP13596
Alternative Names
CD63 Molecule; Lysosomal-Associated Membrane Protein 3; Ocular Melanoma-Associated Antigen; CD63 Antigen (Melanoma 1 Antigen); Melanoma-Associated Antigen ME491; Tetraspanin-30; Granulophysin; CD63 Antigen; Tspan-30;
Function
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

(Microbial infection) Acts as a receptor for rabies virus.

(Microbial infection) Acts as a receptor for Zika virus.
Biological Process
Cell adhesion Source: ProtInc
Commissural neuron axon guidance Source: ARUK-UCL
Regulation of semaphorin-plexin signaling pathway Source: ARUK-UCL
Cellular Location
Isoform 1&2&3&4: Cell membrane
Isoform 5&6: Secreted
Topology
Extracellular: 20-718
Helical: 719-739
Cytoplasmic: 740-858

Kim, W., Watanabe, H., Lomoio, S., & Tesco, G. (2021). Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. Journal of Biological Chemistry, 296.

Caza, T. N., Hassen, S. I., Kuperman, M., Sharma, S. G., Dvanajscak, Z., Arthur, J., ... & Larsen, C. P. (2021). Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kidney international, 100(1), 171-181.

Vukojevic, V., Mastrandreas, P., Arnold, A., Peter, F., Kolassa, I. T., Wilker, S., ... & Stetak, A. (2020). Evolutionary conserved role of neural cell adhesion molecule-1 in memory. Translational psychiatry, 10(1), 217.

Jesudas, B. R., Nandeesha, H., Menon, V., & Allimuthu, P. (2020). Relationship of elevated neural cell adhesion molecule 1 with interleukin-10 and disease severity in bipolar disorder. Asian Journal of Psychiatry, 47, 101849.

Kim, Y. H., Kim, Y. H., Shin, Y. K., Jo, Y. R., Park, D. K., Song, M. Y., ... & Park, H. T. (2019). p75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies. Annals of Clinical and Translational Neurology, 6(7), 1292-1301.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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