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Rat Anti-NCAM2 Recombinant Antibody (10C39) (CBMAB-N1352-WJ)

This product is a Rat antibody that recognizes NCAM2. The antibody 10C39 can be used for immunoassay techniques such as: WB.
See all NCAM2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
10C39
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neural Cell Adhesion Molecule 2
Introduction
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
Entrez Gene ID
17968
UniProt ID
O35136
Alternative Names
Neural Cell Adhesion Molecule 2; N-CAM-2; NCAM-2; NCAM21;
Function
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
Biological Process
Axonal fasciculation Source: Ensembl
Neuron cell-cell adhesion Source: ProtInc
Sensory perception of smell Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 20-697
Helical: 698-718
Cytoplasmic: 719-837

Ortega-Gascó, A., Parcerisas, A., Hino, K., Herranz-Pérez, V., Ulloa, F., Elias-Tersa, A., ... & Soriano, E. (2023). Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2). Cerebral Cortex, 33(21), 10931-10948.

Sah, S., Keable, R., Pfundstein, G., Clemens, K. J., Begg, D., Schachner, M., ... & Sytnyk, V. (2023). Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits. Cerebral Cortex, 33(18), 10047-10065.

Keable, R., Hu, S., Pfundstein, G., Kozlova, I., Su, F., Du, X., ... & Sytnyk, V. (2022). The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes. Cellular and Molecular Life Sciences, 79(11), 555.

Kim, W., Watanabe, H., Lomoio, S., & Tesco, G. (2021). Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. Journal of Biological Chemistry, 296.

Parcerisas, A., Ortega-Gascó, A., Pujadas, L., & Soriano, E. (2021). The hidden side of NCAM family: NCAM2, a key cytoskeleton organization molecule regulating multiple neural functions. International Journal of Molecular Sciences, 22(18), 10021.

Sheng, L., Leshchyns’ ka, I., & Sytnyk, V. (2019). Neural cell adhesion molecule 2 (NCAM2)-induced c-Src-dependent propagation of submembrane Ca2+ spikes along dendrites inhibits synapse maturation. Cerebral Cortex, 29(4), 1439-1459.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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