Human Recombinant NCAM2 protein, His Tag (V2LY-0526-LY5707)

Name: Human Recombinant NCAM2 protein, His Tag
SKU: V2LY-0526-LY5707
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant NCAM2 protein, His Tag consist of Amino Acid: 1-697 and predicts a molecular mass of 77.4 kDa.

Molecule Mass

77.4 kDa

Sequence

Amino Acid: 1-697

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Neural Cell Adhesion Molecule 2

Function

May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

Biological Process

Axonal fasciculation Source: Ensembl
Neuron cell-cell adhesion Source: ProtInc
Sensory perception of smell Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 20-697
Helical: 698-718
Cytoplasmic: 719-837

Ortega-Gascó, A., Parcerisas, A., Hino, K., Herranz-Pérez, V., Ulloa, F., Elias-Tersa, A., ... & Soriano, E. (2023). Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2). Cerebral Cortex, 33(21), 10931-10948.

Sah, S., Keable, R., Pfundstein, G., Clemens, K. J., Begg, D., Schachner, M., ... & Sytnyk, V. (2023). Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits. Cerebral Cortex, 33(18), 10047-10065.

Keable, R., Hu, S., Pfundstein, G., Kozlova, I., Su, F., Du, X., ... & Sytnyk, V. (2022). The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes. Cellular and Molecular Life Sciences, 79(11), 555.

Kim, W., Watanabe, H., Lomoio, S., & Tesco, G. (2021). Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. Journal of Biological Chemistry, 296.

Parcerisas, A., Ortega-Gascó, A., Pujadas, L., & Soriano, E. (2021). The hidden side of NCAM family: NCAM2, a key cytoskeleton organization molecule regulating multiple neural functions. International Journal of Molecular Sciences, 22(18), 10021.

Sheng, L., Leshchyns’ ka, I., & Sytnyk, V. (2019). Neural cell adhesion molecule 2 (NCAM2)-induced c-Src-dependent propagation of submembrane Ca2+ spikes along dendrites inhibits synapse maturation. Cerebral Cortex, 29(4), 1439-1459.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NCAM2 protein, hFc Tag (CAT#: V2LY-0526-LY5706)

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Human Recombinant NCAM2 protein, hFc Tag (CAT#: V2LY-0526-LY5706)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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