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Mouse Anti-NCAN Recombinant Antibody (1F6) (CBMAB-0079-CN)

This product is a mouse antibody that recognizes NCAN of rat. The antibody 1F6 can be used for immunoassay techniques such as: IHC-P, BL, IF, IHC, IP, WB.
See all NCAN antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
1F6
Antibody Isotype
IgG1
Application
IHC-P, Blocking, IF, IHC, IP, WB

Basic Information

Immunogen
PBS-soluble chondroitin sulfate proteoglycans.
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurocan
Introduction
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration. It may modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM).
Entrez Gene ID
58982
UniProt ID
P55067
Alternative Names
Cspg3; LOC100911345
Function
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Biological Process
Cell adhesion Source: UniProtKB-KW
Central nervous system development Source: GO_Central
Skeletal system development Source: GO_Central
Cellular Location
Secreted
PTM
O-glycosylated.

Baidoe-Ansah, D., Mirzapourdelavar, H., Aleshin, S., Schott, B. H., Seidenbecher, C., Kaushik, R., & Dityatev, A. I. (2024). Neurocan regulates axon initial segment organization and neuronal activity in cultured cortical neurons. bioRxiv, 2024-01.

Hu, R., He, K., Chen, B., Chen, Y., Zhang, J., Wu, X., ... & Ma, R. (2024). Electroacupuncture promotes the repair of the damaged spinal cord in mice by mediating neurocan‐perineuronal net. CNS Neuroscience & Therapeutics.

Janik, K., Smith, G. M., & Krynska, B. (2023). Identification of Neurocan and Phosphacan as Early Biomarkers for Open Neural Tube Defects. Cells, 12(7), 1084.

Baidoe-Ansah, D., Mirzapourdelavar, H., Carceller, H., Perez, M., Strackeljan, L., Garcia, B., ... & Dityatev, A. (2023). Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervation. bioRxiv, 2023-04.

Salmikangas, M., Laaksonen, M., Edgren, H., Salgado, M., Suoranta, A., Mattila, P., ... & Sihto, H. (2023). Neurocan expression associates with better survival and viral positivity in Merkel cell carcinoma. Plos one, 18(5), e0285524.

Irala, D., Wang, S., Sakers, K., Nagendren, L., Ulloa-Severino, F. P., Bindu, D. S., & Eroglu, C. (2023). Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function. bioRxiv, 2023-04.

Assmann, A., Richter, A., Schütze, H., Soch, J., Barman, A., Behnisch, G., ... & Schott, B. H. (2021). Neurocan genome‐wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans. European Journal of Neuroscience, 53(12), 3942-3959.

Schmidt, S., Arendt, T., Morawski, M., & Sonntag, M. (2020). Neurocan contributes to perineuronal net development. Neuroscience, 442, 69-86.

Heusinger, J., Hildebrandt, H., & Illing, R. B. (2019). Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem. Brain and Behavior, 9(8), e01353.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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