Human NCAN ELISA Kit (V2LY-0626-LY4944)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.056 ng/mL
Detection Range
0.1-40 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
143.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Neurocan
Function
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Biological Process
Cell adhesion Source: UniProtKB-KW
Central nervous system development Source: GO_Central
Skeletal system development Source: GO_Central
Cellular Location
Secreted
PTM
O-glycosylated.

Baidoe-Ansah, D., Mirzapourdelavar, H., Aleshin, S., Schott, B. H., Seidenbecher, C., Kaushik, R., & Dityatev, A. I. (2024). Neurocan regulates axon initial segment organization and neuronal activity in cultured cortical neurons. bioRxiv, 2024-01.

Hu, R., He, K., Chen, B., Chen, Y., Zhang, J., Wu, X., ... & Ma, R. (2024). Electroacupuncture promotes the repair of the damaged spinal cord in mice by mediating neurocan‐perineuronal net. CNS Neuroscience & Therapeutics.

Janik, K., Smith, G. M., & Krynska, B. (2023). Identification of Neurocan and Phosphacan as Early Biomarkers for Open Neural Tube Defects. Cells, 12(7), 1084.

Baidoe-Ansah, D., Mirzapourdelavar, H., Carceller, H., Perez, M., Strackeljan, L., Garcia, B., ... & Dityatev, A. (2023). Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervation. bioRxiv, 2023-04.

Salmikangas, M., Laaksonen, M., Edgren, H., Salgado, M., Suoranta, A., Mattila, P., ... & Sihto, H. (2023). Neurocan expression associates with better survival and viral positivity in Merkel cell carcinoma. Plos one, 18(5), e0285524.

Irala, D., Wang, S., Sakers, K., Nagendren, L., Ulloa-Severino, F. P., Bindu, D. S., & Eroglu, C. (2023). Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function. bioRxiv, 2023-04.

Assmann, A., Richter, A., Schütze, H., Soch, J., Barman, A., Behnisch, G., ... & Schott, B. H. (2021). Neurocan genome‐wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans. European Journal of Neuroscience, 53(12), 3942-3959.

Schmidt, S., Arendt, T., Morawski, M., & Sonntag, M. (2020). Neurocan contributes to perineuronal net development. Neuroscience, 442, 69-86.

Heusinger, J., Hildebrandt, H., & Illing, R. B. (2019). Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem. Brain and Behavior, 9(8), e01353.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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