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Mouse Anti-NCF4 Recombinant Antibody (3C10) (CBMAB-N1393-WJ)

This product is a Mouse antibody that recognizes NCF4. The antibody 3C10 can be used for immunoassay techniques such as: ELISA.
See all NCF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C10
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neutrophil Cytosolic Factor 4
Introduction
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4689
UniProt ID
Q15080
Alternative Names
Neutrophil Cytosolic Factor 4; Neutrophil NADPH Oxidase Factor 4; SH3 And PX Domain-Containing Protein 4; Neutrophil Cytosolic Factor 4, 40kDa; P40-Phox; P40PHOX; SH3PXD4;
Function
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
Biological Process
Phagocytosis Source: InterPro
Respiratory burst Source: ComplexPortal
Superoxide anion generation Source: UniProtKB
Cellular Location
Endosome
Endosome membrane
Cytosol
Other locations
Membrane
Involvement in disease
Granulomatous disease, chronic, autosomal recessive, 3 (CGD3):
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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