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Mouse Anti-NDUFS3 Recombinant Antibody (3F9DD2) (CBMAB-N0215-WJ)

This product is a Mouse antibody that recognizes NDUFS3. The antibody 3F9DD2 can be used for immunoassay techniques such as: WB, IHC-P, IHC-Fr, FC, ICC, IHC.
See all NDUFS3 antibodies
Published Data
Fig.1 The expression levels of the subunits of mitochondrial respiratory enzymes (NDUFS3, SDHA, UQCRC1, COX-2, and ATPB) as shown by western blots.
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Fig.2 Representative images of NDUFS3 and COX IV immunofluorescence.
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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Cattle, Human, Zebrafish
Clone
3F9DD2
Antibody Isotype
IgG1
Application
WB, IHC-P, IHC-Fr, FC, ICC, IHC

Basic Information

Specificity
Mouse, Rat, Cattle, Human, Zebrafish
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
Introduction
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]
Entrez Gene ID
Human4722
Mouse68349
Rat295923
Cattle287327
Zebrafish550451
UniProt ID
HumanO75489
MouseQ9DCT2
RatD3ZG43
CattleP23709
ZebrafishQ566S4
Alternative Names
NADH:Ubiquinone Oxidoreductase Core Subunit S3; NADH Dehydrogenase (Ubiquinone) Fe-S Protein 3, 30kDa (NADH-Coenzyme Q Reductase); NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 3, Mitochondrial; NADH-Ubiquinone Oxidoreductase 30 KDa Subunit; Complex I 30kDa Subunit; Complex I-30kD; CI-30kD;
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14729820, PubMed:30140060).

Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060).
Biological Process
Aerobic respiration Source: ComplexPortal
Mitochondrial ATP synthesis coupled proton transport Source: ComplexPortal
Mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
Mitochondrial respiratory chain complex I assembly Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Reactive oxygen species metabolic process Source: UniProtKB
Substantia nigra development Source: UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial complex I deficiency, nuclear type 8 (MC1DN8):
A form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN8 transmission pattern is consistent with autosomal recessive inheritance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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