Mouse Anti-NECTIN1 Recombinant Antibody (CBWJN-0081) (CBMAB-N1721-WJ)

Name: Mouse Anti-NECTIN1 Recombinant Antibody (CBWJN-0081)
SKU: CBMAB-N1721-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0081

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.5% BSA

Preservative

0.09% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nectin Cell Adhesion Molecule 1

Introduction

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

Entrez Gene ID

5818

UniProt ID

Q15223

Alternative Names

Nectin Cell Adhesion Molecule 1; Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C); Poliovirus Receptor-Related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Ig-Like Receptor; PVRL1; HVEC; HIgR; PRR1; Ectodermal Dysplasia 4 (Margarita Island Type); Herpes Simplex Virus Type 1 Sensitivity; Herpesvirus Entry Mediator C; Poliovirus Receptor-Like 1; CD111 Antigen;

Function

Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.

(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.

Biological Process

Axon guidance Source: Ensembl
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Desmosome organization Source: Ensembl
Enamel mineralization Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Immune response Source: UniProtKB
Iron ion transport Source: Ensembl
Lens morphogenesis in camera-type eye Source: Ensembl
Protein localization to cell junction Source: GO_Central
Regulation of synapse assembly Source: Ensembl
Retina development in camera-type eye Source: Ensembl
Viral entry into host cell Source: UniProtKB
Virion attachment to host cell Source: InterPro

Cellular Location

Isoform Alpha:
Plasma membrane
Cell membrane
presynaptic cell membrane
Isoform Delta:
Plasma membrane
Cell membrane
Isoform Gamma:
Secreted

Involvement in disease

Ectodermal dysplasia, Margarita Island type (EDMI):
An autosomal recessive form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.
Non-syndromic orofacial cleft 7 (OFC7):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.

Topology

Extracellular: 31-355
Helical: 356-376
Cytoplasmic: 377-517

Liu, X., An, T., Li, D., Fan, Z., Xiang, P., Li, C., ... & Peng, X. (2019). Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules. Proceedings of the National Academy of Sciences, 116(6), 2068-2077.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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