Sign in or Register   Sign in or Register
  |  

Mouse Anti-NECTIN1 Recombinant Antibody (CK8) (CBMAB-N1726-WJ)

This product is a Mouse antibody that recognizes NECTIN1. The antibody CK8 can be used for immunoassay techniques such as: ELISA, FC, IP, WB.
See all NECTIN1 antibodies
Published Data
Fig.1 Effects of NMHC-IIB knock-down on HSV-1 infection and cell-cell fusion.
...View More

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CK8
Antibody Isotype
IgG1, κ
Application
ELISA, FC, IP, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nectin Cell Adhesion Molecule 1
Introduction
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
Entrez Gene ID
Human5818
Mouse58235
Rat192183
UniProt ID
HumanQ15223
MouseQ9JKF6
RatF1LNP8
Alternative Names
Nectin Cell Adhesion Molecule 1; Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C); Poliovirus Receptor-Related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Ig-Like Receptor; PVRL1; HVEC; HIgR; PRR1; Ectodermal Dysplasia 4 (Margarita Island Type); Herpes Simplex Virus Type 1 Sensitivity; Herpesvirus Entry Mediator C; Poliovirus Receptor-Like 1; CD111 Antigen;
Function
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.

(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.
Biological Process
Axon guidance Source: Ensembl
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Desmosome organization Source: Ensembl
Enamel mineralization Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Immune response Source: UniProtKB
Iron ion transport Source: Ensembl
Lens morphogenesis in camera-type eye Source: Ensembl
Protein localization to cell junction Source: GO_Central
Regulation of synapse assembly Source: Ensembl
Retina development in camera-type eye Source: Ensembl
Viral entry into host cell Source: UniProtKB
Virion attachment to host cell Source: InterPro
Cellular Location
Isoform Alpha:
Plasma membrane
Cell membrane
presynaptic cell membrane
Isoform Delta:
Plasma membrane
Cell membrane
Isoform Gamma:
Secreted
Involvement in disease
Ectodermal dysplasia, Margarita Island type (EDMI):
An autosomal recessive form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.
Non-syndromic orofacial cleft 7 (OFC7):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Topology
Extracellular: 31-355
Helical: 356-376
Cytoplasmic: 377-517
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NECTIN1 Recombinant Antibody (CK8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare