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Rabbit Anti-NECTIN2 Recombinant Antibody (CBYY-C2702) (CBMAB-C4143-YY)

This product is rabbit antibody that recognizes NECTIN2. The antibody CBYY-C2702 can be used for immunoassay techniques such as: FC
See all NECTIN2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-C2702
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant Human CD112/Nectin-2 protein. This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112/Nectin-2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nectin cell adhesion molecule 2
Entrez Gene ID
UniProt ID
Alternative Names
CPR, CYPOR, P450R
Function
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705).

Probable cell adhesion protein (PubMed:9657005).

(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Biological Process
Acrosome assembly Source: GO_Central
Adhesion of symbiont to host Source: BHF-UCL
Cell part morphogenesis Source: Ensembl
Cilium organization Source: Ensembl
Coreceptor-mediated virion attachment to host cell Source: BHF-UCL
Cytoskeleton organization Source: GO_Central
Establishment of mitochondrion localization Source: GO_Central
Fertilization Source: Ensembl
Fusion of virus membrane with host plasma membrane Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of viral entry into host cell Source: CACAO
Spermatid development Source: BHF-UCL
Spermatid nucleus differentiation Source: Ensembl
Sperm mitochondrion organization Source: Ensembl
Susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
Susceptibility to T cell mediated cytotoxicity Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 32-360
Helical: 361-381
Cytoplasmic: 382-538
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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