NECTIN2
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Full Name
nectin cell adhesion molecule 2
Function
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705).
Probable cell adhesion protein (PubMed:9657005).
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Probable cell adhesion protein (PubMed:9657005).
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Biological Process
Acrosome assembly Source: GO_Central
Adhesion of symbiont to host Source: BHF-UCL
Cell part morphogenesis Source: Ensembl
Cilium organization Source: Ensembl
Coreceptor-mediated virion attachment to host cell Source: BHF-UCL
Cytoskeleton organization Source: GO_Central
Establishment of mitochondrion localization Source: GO_Central
Fertilization Source: Ensembl
Fusion of virus membrane with host plasma membrane Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of viral entry into host cell Source: CACAO
Spermatid development Source: BHF-UCL
Spermatid nucleus differentiation Source: Ensembl
Sperm mitochondrion organization Source: Ensembl
Susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
Susceptibility to T cell mediated cytotoxicity Source: BHF-UCL
Adhesion of symbiont to host Source: BHF-UCL
Cell part morphogenesis Source: Ensembl
Cilium organization Source: Ensembl
Coreceptor-mediated virion attachment to host cell Source: BHF-UCL
Cytoskeleton organization Source: GO_Central
Establishment of mitochondrion localization Source: GO_Central
Fertilization Source: Ensembl
Fusion of virus membrane with host plasma membrane Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of viral entry into host cell Source: CACAO
Spermatid development Source: BHF-UCL
Spermatid nucleus differentiation Source: Ensembl
Sperm mitochondrion organization Source: Ensembl
Susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
Susceptibility to T cell mediated cytotoxicity Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 32-360
Helical: 361-381
Cytoplasmic: 382-538
Helical: 361-381
Cytoplasmic: 382-538
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Anti-NECTIN2 antibodies
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CompareTarget: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: CBHb038
Application*: FC, IHC-F, Immuno assays, IP, WB
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 502-57
Application*: WB, IP, E, C
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 11E1
Application*: WB, E, IP
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 013
Application*: E
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3052
Application*: F
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR071G
Application*: WB, IHC, ICC, IHC-IF
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A6-2C1
Application*: WB, E
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: R2.477
Application*: F
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBFYA-0023
Application*: F, C, IA, IP, WB
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1817
Application*: FC, IH, IP
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4249
Application*: E
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1814
Application*: F, IH
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: TX31
Application*: F
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P116
Application*: F, IH, IP
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R2-525
Application*: F, C, IP
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-C12
Application*: P
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 13A61
Application*: E, F, C, IP, WB
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2703
Application*: F
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2702
Application*: F
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYY-C0305
Application*: WB, IP, E, C
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3002
Application*: F
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-3001
Application*: WB, E, IP
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYC-3000
Application*: E
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0028
Application*: E, EC, F
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 017
Application*: E
Target: NECTIN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 005
Application*: E, EC, F
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R2.525
Application*: F, C, IP
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBWJN-0430
Application*: E, F, IH, IP, WB
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJN-0331
Application*: E, IP, WB
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBWJN-0121
Application*: F, IH, IP, WB
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0565
Application*: C, F, IC
Target: NECTIN2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJN-0970
Application*: F, MC
Target: NECTIN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0969
Application*: F, IC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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