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NECTIN2

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Full Name

nectin cell adhesion molecule 2

Function

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705).

Probable cell adhesion protein (PubMed:9657005).

(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Biological Process

Acrosome assembly Source: GO_Central
Adhesion of symbiont to host Source: BHF-UCL
Cell part morphogenesis Source: Ensembl
Cilium organization Source: Ensembl
Coreceptor-mediated virion attachment to host cell Source: BHF-UCL
Cytoskeleton organization Source: GO_Central
Establishment of mitochondrion localization Source: GO_Central
Fertilization Source: Ensembl
Fusion of virus membrane with host plasma membrane Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of viral entry into host cell Source: CACAO
Spermatid development Source: BHF-UCL
Spermatid nucleus differentiation Source: Ensembl
Sperm mitochondrion organization Source: Ensembl
Susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
Susceptibility to T cell mediated cytotoxicity Source: BHF-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 32-360
Helical: 361-381
Cytoplasmic: 382-538

Anti-NECTIN2 antibodies

Rat Anti-NECTIN2 Recombinant Antibody (CBFYA-0023) (CBMAB-X0038-FY)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBFYA-0023

Application*: F, C, IA, IP, WB

Rat Anti-NECTIN2 Recombinant Antibody (502-57) (CBMAB-C2600-LY)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 502-57

Application*: WB, IP, E, C

Rabbit Anti-NECTIN2 Recombinant Antibody (11E1) (CBMAB-C2426-LY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 11E1

Application*: WB, E, IP

Rabbit Anti-NECTIN2 Recombinant Antibody (013) (CBMAB-C1620-LY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: 013

Application*: E

Mouse Anti-NECTIN2 Recombinant Antibody (2A6-2C1) (CBMAB-A7267-LY)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2A6-2C1

Application*: WB, E

Rabbit Anti-NECTIN2 Recombinant Antibody (CBR071G) (CBMAB-BT064LY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBR071G

Application*: WB, IHC, ICC, IHC-IF

Recombinant Rat Anti-NECTIN2 Antibody (CBHb038) (CBMAB-Hb815-LY)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse, Human

Clone: CBHb038

Application*: FC, IHC-F, Immuno assays, IP, WB

Mouse Anti-NECTIN2 Recombinant Antibody (R2.477) (CBMAB-C12138-LY)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: R2.477

Application*: F

Mouse Anti-NECTIN2 Recombinant Antibody (3H1817) (CBMAB-C4028-CN)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3H1817

Application*: FC, IH, IP

Mouse Anti-NECTIN2 Recombinant Antibody (CBWJC-4249) (CBMAB-C5604WJ)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4249

Application*: E

Mouse Anti-NECTIN2 Recombinant Antibody (CBXC-1814) (CBMAB-C5574-CQ)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-1814

Application*: F, IH

Rat Anti-NECTIN2 Recombinant Antibody (TX31) (CBMAB-C5573-CQ)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: TX31

Application*: F

Mouse Anti-NECTIN2 Recombinant Antibody (CBYC-P116) (CBMAB-P0550-YC)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P116

Application*: F, IH, IP

Mouse Anti-NECTIN2 Recombinant Antibody (R2-525) (CBMAB-P0549-YC)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: R2-525

Application*: F, C, IP

Mouse Anti-NECTIN2 Recombinant Antibody (B-C12) (CBMAB-P0548-YC)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: B-C12

Application*: P

Rat Anti-NECTIN2 Recombinant Antibody (13A61) (CBMAB-P0546-YC)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 13A61

Application*: E, F, C, IP, WB

Mouse Anti-NECTIN2 Recombinant Antibody (CBYY-C2703) (CBMAB-C4144-YY)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-C2703

Application*: F

Rabbit Anti-NECTIN2 Recombinant Antibody (CBYY-C2702) (CBMAB-C4143-YY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-C2702

Application*: F

Rat Anti-NECTIN2 Recombinant Antibody (CBYY-C0305) (CBMAB-C1025-YY)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBYY-C0305

Application*: WB, IP, E, C

Mouse Anti-NECTIN2 Recombinant Antibody (CBFYC-3002) (CBMAB-C3079-FY)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3002

Application*: F

Rabbit Anti-NECTIN2 Recombinant Antibody (CBFYC-3001) (CBMAB-C3078-FY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-3001

Application*: WB, E, IP

Rabbit Anti-NECTIN2 Recombinant Antibody (CBFYC-3000) (CBMAB-C3077-FY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: CBFYC-3000

Application*: E

Rabbit Anti-NECTIN2 Recombinant Antibody (CBFYC-0028) (CBMAB-C0035-FY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-0028

Application*: E, EC, F

Rabbit Anti-NECTIN2 Recombinant Antibody (017) (CBMAB-C1640-LY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 017

Application*: E

Rabbit Anti-NECTIN2 Recombinant Antibody (005) (CBMAB-C0024-LY)

SDS

Target: NECTIN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 005

Application*: E, EC, F

Mouse Anti-NECTIN2 Recombinant Antibody (R2.525) (CBMAB-N1734-WJ)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: R2.525

Application*: F, C, IP

Rat Anti-NECTIN2 Recombinant Antibody (CBWJN-0430) (CBMAB-N1731-WJ)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBWJN-0430

Application*: E, F, IH, IP, WB

Mouse Anti-NECTIN2 Recombinant Antibody (CBWJN-0331) (CBMAB-N1730-WJ)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJN-0331

Application*: E, IP, WB

Rat Anti-NECTIN2 Recombinant Antibody (CBWJN-0121) (CBMAB-N1729-WJ)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBWJN-0121

Application*: F, IH, IP, WB

Mouse Anti-NECTIN2 Recombinant Antibody (CBWJN-0565) (CBMAB-N0220-WJ)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-0565

Application*: C, F, IC

Rat Anti-NECTIN2 Recombinant Antibody (CBWJN-0970) (CBMAB-N0219-WJ)

SDS

Target: NECTIN2

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBWJN-0970

Application*: F, MC

Mouse Anti-NECTIN2 Recombinant Antibody (CBWJN-0969) (CBMAB-N0218-WJ)

SDS

Target: NECTIN2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0969

Application*: F, IC

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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