Rat Anti-NECTIN4 Recombinant Antibody (7H130) (CBMAB-N1742-WJ)

Name: Rat Anti-NECTIN4 Recombinant Antibody (7H130)
SKU: CBMAB-N1742-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

7H130

Application

ELISA, WB

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 5% Trehalose

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nectin Cell Adhesion Molecule 4

Introduction

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

Entrez Gene ID

Human	81607
Mouse	71740

UniProt ID

Human	Q96NY8
Mouse	Q8R007

Alternative Names

Nectin Cell Adhesion Molecule 4; Poliovirus Receptor-Related Protein 4; Poliovirus Receptor-Related 4; Ig Superfamily Receptor LNIR; PVRL4; LNIR;

Function

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

(Microbial infection) Acts as a receptor for measles virus.

Biological Process

Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central

Cellular Location

Plasma membrane
Cell membrane
Other locations
adherens junction
Note: Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).
Processed poliovirus receptor-related protein 4:
Secreted 1 Publication
Note: The secreted form is found in breast tumor patients (PubMed:15784625).

Involvement in disease

Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.

Topology

Extracellular: 32-349
Helical: 350-370
Cytoplasmic: 371-510

PTM

The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.

Tanaka, Y., Murata, M., Tanegashima, K., Oda, Y., & Ito, T. (2022). Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma. Scientific reports, 12(1), 4031.

Bouleftour, W., Guillot, A., & Magne, N. (2022). The anti-nectin 4: A promising tumor cells target. A systematic review. Molecular Cancer Therapeutics, 21(4), 493-501.

Chatterjee, S., Sinha, S., & Kundu, C. N. (2021). Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy. European Journal of Pharmacology, 911, 174516.

Tanaka, Y., Murata, M., Oda, Y., Furue, M., & Ito, T. (2021). Nectin cell adhesion molecule 4 (NECTIN4) expression in cutaneous squamous cell carcinoma: A new therapeutic target?. Biomedicines, 9(4), 355.

Liu, Y., Han, X., Li, L., Zhang, Y., Huang, X., Li, G., ... & Wang, G. (2021). Role of Nectin‑4 protein in cancer. International Journal of Oncology, 59(5), 1-14.

Tanaka, Y., Murata, M., Shen, C. H., Furue, M., & Ito, T. (2021). NECTIN4: A novel therapeutic target for melanoma. International journal of molecular sciences, 22(2), 976.

Krishnan, R., Qadiri, S. S. N., & Oh, M. J. (2019). Functional characterization of seven-band grouper immunoglobulin like cell adhesion molecule, Nectin4 as a cellular receptor for nervous necrosis virus. Fish & Shellfish Immunology, 93, 720-725.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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