Human Recombinant NECTIN4 protein, ECD, His Tag-1 (V2LY-0526-LY5725)

Name: Human Recombinant NECTIN4 protein, ECD, His Tag-1
SKU: V2LY-0526-LY5725
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant NECTIN4 protein, ECD, His Tag consist of Amino Acid: 1-349 and predicts a molecular mass of 35.56 kDa.

Molecule Mass

35.56 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 1-349

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC. ≥90% as determined by SEC-MALS(Routinely tested).

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Nectin Cell Adhesion Molecule 4

Function

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

(Microbial infection) Acts as a receptor for measles virus.

Biological Process

Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central

Cellular Location

Plasma membrane
Cell membrane
Other locations
adherens junction
Note: Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).
Processed poliovirus receptor-related protein 4:
Secreted 1 Publication
Note: The secreted form is found in breast tumor patients (PubMed:15784625).

Involvement in disease

Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.

Topology

Extracellular: 32-349
Helical: 350-370
Cytoplasmic: 371-510

PTM

The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.

Tanaka, Y., Murata, M., Tanegashima, K., Oda, Y., & Ito, T. (2022). Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma. Scientific reports, 12(1), 4031.

Bouleftour, W., Guillot, A., & Magne, N. (2022). The anti-nectin 4: A promising tumor cells target. A systematic review. Molecular Cancer Therapeutics, 21(4), 493-501.

Chatterjee, S., Sinha, S., & Kundu, C. N. (2021). Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy. European Journal of Pharmacology, 911, 174516.

Tanaka, Y., Murata, M., Oda, Y., Furue, M., & Ito, T. (2021). Nectin cell adhesion molecule 4 (NECTIN4) expression in cutaneous squamous cell carcinoma: A new therapeutic target?. Biomedicines, 9(4), 355.

Liu, Y., Han, X., Li, L., Zhang, Y., Huang, X., Li, G., ... & Wang, G. (2021). Role of Nectin‑4 protein in cancer. International Journal of Oncology, 59(5), 1-14.

Tanaka, Y., Murata, M., Shen, C. H., Furue, M., & Ito, T. (2021). NECTIN4: A novel therapeutic target for melanoma. International journal of molecular sciences, 22(2), 976.

Krishnan, R., Qadiri, S. S. N., & Oh, M. J. (2019). Functional characterization of seven-band grouper immunoglobulin like cell adhesion molecule, Nectin4 as a cellular receptor for nervous necrosis virus. Fish & Shellfish Immunology, 93, 720-725.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human NECTIN4 ELISA Kit (CAT#: V2LY-0626-LY3945)

Canine Recombinant NECTIN4 protein, His Tag (CAT#: V2LY-0526-LY1293)

Cynomolgus Recombinant NECTIN4 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1607)

Cynomolgus Recombinant NECTIN4 protein, ECD, His Tag (CAT#: V2LY-0526-LY1608)

Cynomolgus Recombinant NECTIN4 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY1609)

Human Recombinant NECTIN4 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY5722)

Human Recombinant NECTIN4 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5723)

Human Recombinant NECTIN4 protein, ECD, His Tag (CAT#: V2LY-0526-LY5724)

Human Recombinant NECTIN4 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5726)

Human Recombinant NECTIN4 protein, Ig-like V Domain, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5727)

Related Products

Human Recombinant NECTIN4 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5723)

Human Recombinant NECTIN4 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY5722)

Mouse Anti-NECTIN4 Recombinant Antibody (7H96) (CAT#: CBMAB-N1743-WJ)

Rat Anti-NECTIN4 Recombinant Antibody (CBWJN-1289) (CAT#: CBMAB-N1741-WJ)

Human NECTIN4 ELISA Kit (CAT#: V2LY-0626-LY3945)

Mouse Recombinant NECTIN4 protein, ECD, His Tag (CAT#: V2LY-0526-LY8693)

Human Recombinant NECTIN4 protein, Ig-like V Domain, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5727)

Human Anti-NECTIN4 Recombinant Antibody (
6D3) (CAT#: V2LY-0725-LY1388)

Cynomolgus Recombinant NECTIN4 protein, ECD, His Tag (CAT#: V2LY-0526-LY1608)

Rat Anti-NECTIN4 Recombinant Antibody (7H130) (CAT#: CBMAB-N1742-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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