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Rat Anti-NECTIN4 Recombinant Antibody (CBWJN-1289) (CBMAB-N1741-WJ)

This product is a Rat antibody that recognizes NECTIN4. The antibody CBWJN-1289 can be used for immunoassay techniques such as: WB.
See all NECTIN4 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJN-1289
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nectin Cell Adhesion Molecule 4
Introduction
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
Entrez Gene ID
UniProt ID
Alternative Names
Nectin Cell Adhesion Molecule 4; Poliovirus Receptor-Related Protein 4; Poliovirus Receptor-Related 4; Ig Superfamily Receptor LNIR; PVRL4; LNIR;
Function
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

(Microbial infection) Acts as a receptor for measles virus.
Biological Process
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Cellular Location
Plasma membrane
Cell membrane
Other locations
adherens junction
Note: Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).
Processed poliovirus receptor-related protein 4:
Secreted 1 Publication
Note: The secreted form is found in breast tumor patients (PubMed:15784625).
Involvement in disease
Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.
Topology
Extracellular: 32-349
Helical: 350-370
Cytoplasmic: 371-510
PTM
The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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