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Mouse Anti-NELFCD Recombinant Antibody (CBYJT-1491) (CBMAB-T0522-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1491
Antibody Isotype
IgM, κ
Application
ELISA

Basic Information

Immunogen
TH1L (NP_057481.2, 491 a.a. ~ 590 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 491-590

Target

Full Name
Negative Elongation Factor Complex Member C/D
Introduction
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. NELFCD is an necessary part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.
Entrez Gene ID
51497
UniProt ID
Q8IXH7
Alternative Names
Negative Elongation Factor Complex Member C/D; Trihydrophobin 1; TH1-Like Protein; NELF-C/D; TH1L; TH1; Negative Elongation Factor Proteins C And D; Negative Elongation Factor C/D
Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062).

The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).

(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Biological Process
Negative regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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